Lineage-specific biomarkers predict response to FGFR inhibition.
Lineage-specific biomarkers predict response to FGFR inhibition.
复制标题
谱系特异性生物标志物预测对 FGFR 抑制的反应。
DOI：
10.1158/2159-8290.cd-12-0486
复制
发表时间：
2012
期刊：
影响因子：
28.2
通讯作者：
Pollock,PamelaM
中科院分区：
文献类型：
--
作者：
Loch,DavidC;Pollock,PamelaM
在这一期的《癌症发现》中，Guagnano及其同事使用了大量不同的癌细胞系注释集，即癌细胞系百科全书，将全基因组表达和基因组改变数据集与细胞系敏感性数据与新型泛成纤维细胞生长因子受体（FGFR）抑制剂NVP-BGJ 398相关联。他们的发现不仅强调了此类细胞系组在鉴定预测性生物标志物中的临床前用途，而且还强调了FGFR作为有效治疗靶点的出现，其跨越越来越广泛的恶性肿瘤（Cancer Discov; 2（12）; 1081-3）。©2012 AACR。Guagnano等人的评论，第1118页
In this issue ofCancer Discovery, Guagnano and colleagues use a large and diverse annotated collection of cancer cell lines, the Cancer Cell Line Encyclopedia, to correlate whole-genome expression and genomic alteration datasets with cell line sensitivity data to the novel pan-fibroblast growth factor receptor (FGFR) inhibitor NVP-BGJ398. Their findings underscore not only the preclinical use of such cell line panels in identifying predictive biomarkers, but also the emergence of the FGFRs as valid therapeutic targets, across an increasingly broad range of malignancies.Cancer Discov; 2(12); 1081–3. ©2012 AACR.Commentary on Guagnano et al., p. 1118