Cognitive control of complex motor behavior in marmoset monkeys
Cognitive control of complex motor behavior in marmoset monkeys
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DOI：
10.1038/s41467-019-11714-8
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发表时间：
2019-08-22
影响因子：
16.6
通讯作者：
Hage, Steffen R.
中科院分区：
文献类型：
--
作者：
Pomberger, Thomas;Risueno-Segovia, Cristina;Hage, Steffen R.
绒猴在生命科学领域引起了极大的兴趣。与人类大脑解剖学和生理学的相似之处，如颗粒状额叶皮质，以及转基因品系的发展和将啮齿动物神经科学技术转移到小型灵长类动物的可能性，使它们成为一个有前景的神经退行性和神经精神病学模型系统。然而，在高度受控的实验设计中，绒猴是否可以表现出复杂的运动任务--这是研究认知运动行为背后的高阶控制机制的先决条件之一--尚未得到证实。我们表明，在受控的操作条件反射任务中，绒猴可以被训练成对任意视觉线索做出反应的发声行为。我们的结果强调，绒猴是研究复杂运动行为和言语认知控制演变的合适模型。
Marmosets have attracted significant interest in the life sciences. Similarities with human brain anatomy and physiology, such as the granular frontal cortex, as well as the development of transgenic lines and potential for transferring rodent neuroscientific techniques to small primates make them a promising neurodegenerative and neuropsychiatric model system. However, whether marmosets can exhibit complex motor tasks in highly controlled experimental designs-one of the prerequisites for investigating higher-order control mechanisms underlying cognitive motor behavior-has not been demonstrated. We show that marmosets can be trained to perform vocal behavior in response to arbitrary visual cues in controlled operant conditioning tasks. Our results emphasize the marmoset as a suitable model to study complex motor behavior and the evolution of cognitive control underlying speech.