ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart.
ER Stress-Induced Secretion of Proteins and Their Extracellular Functions in the Heart.
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DOI：
10.3390/cells9092066
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发表时间：
2020-09-10
期刊：
影响因子：
6
通讯作者：
Doroudgar S
中科院分区：
文献类型：
--
作者：
Meyer BA;Doroudgar S
Endoplasmic reticulum (ER) stress is a result of conditions that imbalance protein homeostasis or proteostasis at the ER, for example ischemia, and is a common event in various human pathologies, including the diseased heart. Cardiac integrity and function depend on the active secretion of mature proteins from a variety of cell types in the heart, a process that requires an intact ER environment for efficient protein folding and trafficking to the secretory pathway. As a consequence of ER stress, most protein secretion by the ER secretory pathway is decreased. Strikingly, there is a select group of proteins that are secreted in greater quantities during ER stress. ER stress resulting from the dysregulation of ER Ca2+ levels, for instance, stimulates the secretion of Ca2+-binding ER chaperones, especially GRP78, GRP94, calreticulin, and mesencephalic astrocyte-derived neurotrophic factor (MANF), which play a multitude of roles outside the cell, strongly depending on the cell type and tissue. Here we review current insights in ER stress-induced secretion of proteins, particularly from the heart, and highlight the extracellular functions of these proteins, ranging from the augmentation of cardiac cell viability to the modulation of pro- and anti-apoptotic, oncogenic, and immune-stimulatory cell signaling, cell invasion, extracellular proteostasis, and more. Many of the roles of ER stress-induced protein secretion remain to be explored in the heart. This article is part of a special issue entitled “The Role of Proteostasis Derailment in Cardiac Diseases.”
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影响因子：
64.5
作者：
Brodsky JL
通讯作者：
Brodsky JL
影响因子：
4.8
作者：
Corbett, EF;Oikawa, K;Michalak, M
通讯作者：
Michalak, M
影响因子：
11.1
作者：
Araujo N;Hebbar N;Rangnekar VM
通讯作者：
Rangnekar VM
DOI：
10.1074/jbc.ra118.001897
发表时间：
2018-07-27
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Chu H;Chan CM;Zhang X;Wang Y;Yuan S;Zhou J;Au-Yeung RK;Sze KH;Yang D;Shuai H;Hou Y;Li C;Zhao X;Poon VK;Leung SP;Yeung ML;Yan J;Lu G;Jin DY;Gao GF;Chan JF;Yuen KY
通讯作者：
Yuen KY
影响因子：
64.5
作者：
BLOCH, KD;SEIDMAN, JG;SEIDMAN, CE
通讯作者：
SEIDMAN, CE