HIGH MEASLES MORTALITY IN INFANCY RELATED TO INTENSITY OF EXPOSURE
HIGH MEASLES MORTALITY IN INFANCY RELATED TO INTENSITY OF EXPOSURE
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DOI：
10.1016/s0022-3476(86)80569-8
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发表时间：
1986-07-01
影响因子：
5.1
通讯作者：
PEDERSEN, IR
中科院分区：
文献类型：
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作者：
AABY, P;BUKH, J;PEDERSEN, IR
在西非的一个城市社区，对婴儿麻疹感染进行了5年(1979-1983年)的检查。在0至11个月的年龄组中，继发病例(在室内感染)的麻疹死亡率高于指标病例(在屋外感染)，该年龄组的继发病例比例明显高于年龄较大的儿童。与疾病传播的社会模式有关的密集接触可能是解释发展中国家观察到的麻疹高婴儿死亡率的重要原因。出生后头12个月的死亡率随着年龄的增长而增加，这可能是由于母源性麻疹抗体的减少所致。在6个月以下的儿童中，通常被认为受到母体抗体的保护，密集暴露可能会导致感染，一些暴露在患有麻疹的大龄儿童中的麻疹特异性抗体水平很高就证明了这一点。公共卫生政策的目标应该是改变暴露条件。
In a West African urban community, measles infection in infants was examined over 5 years (1979-1983). In the age group 0 to 11 months, measles mortality was higher among secondary cases (infected in the house) than among index cases (infected outside the house), and the proportion of secondary cases was significantly higher for this age group than for older children. Intensive exposure related to the social pattern of disease transmission may be important in explaining the high infant mortality observed with measles in developing countries. Mortality during the first 12 months of life increased with age, presumably because of the decrease of maternally derived measles antibodies. In children younger than 6 months of age, who are usually considered to be protected by maternal antibody, intensive exposure may lead to infection, as demonstrated by a high level of measles-specific antibodies in some children exposed to an older sibiling with measles. The aim of public health policies should be to change conditions of exposure.