Role of cancer-associated fibroblasts in breast cancer development and prognosis
Role of cancer-associated fibroblasts in breast cancer development and prognosis
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DOI：
10.1387/ijdb.113362aa
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发表时间：
2011-01-01
影响因子：
0.7
通讯作者：
Aboussekhra, Abdelilah
中科院分区：
文献类型：
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作者：
Aboussekhra, Abdelilah
自1889年佩吉特关于癌症生长和转移的“种子和土壤”假说以来，对各种实体瘤的几项研究已经证实了肿瘤环境对肿瘤细胞的发生、生长和扩散的积极作用。成纤维细胞构成肿瘤微环境（基质）的主要成分，因此是研究最多的细胞类型。因此，大量的数据显示这些细胞通过旁分泌作用促进癌症的发生，这些旁分泌作用伴随肿瘤细胞通过所有的致癌步骤。这涉及许多信号蛋白，它们在两个方向上传递信息，允许癌细胞和它们的基质之间的合作串扰。这促使一些研究人员研究活性基质成纤维细胞的分子和细胞特征的潜在用途，以产生用于预防，预后和治疗癌症的特定工具。在此，我回顾了活跃的癌症相关成纤维细胞的细胞和分子特征及其起源。此外，我总结了我们目前对这些细胞的致癌作用及其对乳腺癌患者的潜在预后价值的理解。
Since Paget's "Seed and Soil" hypothesis in 1889 on cancer growth and metastasis, several studies on various solid tumors have confirmed the active role of the tumor milieu on the onset, growth and spread of neoplastic cells. Fibroblasts constitute the major components of the tumor microenvironment (stroma), and are therefore the most studied cell type. Therefore, a large amount of data has emerged showing the cancer-promoting function of these cells through paracrine effects that escort tumor cells through all the carcinogenesis steps. This involves many signaling proteins that transmit the message in both directions, allowing cooperative crosstalk between cancer cells and their stroma. This prompted several researchers to investigate the potential use of the molecular and cellular features of active stromal fibroblasts to generate specific tools for prevention, prognosis and treatment of cancer. Herein, I review the cellular and molecular features of active cancer-associated fibroblasts and their origin. Additionally, I summarize our current understanding of the procarcinogenic actions of these cells and their potential prognostic value for breast cancer patients.