Association study of long non-coding RNA HOTAIR rs920778 polymorphism with the risk of cancer in an elderly Japanese population
Association study of long non-coding RNA HOTAIR rs920778 polymorphism with the risk of cancer in an elderly Japanese population
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DOI：
10.1016/j.gene.2019.144263
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发表时间：
2020-03-01
期刊：
影响因子：
3.5
通讯作者：
Muramatsu, Masaaki
中科院分区：
文献类型：
--
作者：
Minn, Aye Ko Ko;Sato, Noriko;Muramatsu, Masaaki
HOTAIR基因编码长链非编码RNA（IncRNA），其在发育和肿瘤发生中起作用。HOTAIR基因中的单核苷酸多态性（SNP）rs 920778已被反复研究用于许多癌症的易感性，包括食管癌、胃癌、肺癌和肝细胞癌。这些研究大多在中国人群中进行，少数在土耳其，伊朗和葡萄牙人群中进行。它们大多产生有争议的结果。在很大程度上仍然不清楚日本人群是否具有癌症风险。在这里，我们建立了一个代表性的SNP rs 920778的关联研究，以检查它的贡献，在连续的尸检病例中的癌症在JG-SNP数据库的存在。共分析了1373例受试者（平均年龄80岁），包括827例癌症阳性受试者和546例癌症阴性受试者。因此，总体癌症的发生与rs 920778多态性无关（p > 0.05）。对于每种癌症类型，除了肺癌（p = 0.04）外，我们没有发现相关性，肺癌在多次测试后更可能是偶然的相关性。我们的研究结果表明，rs 920778多态性并不影响总的癌症存在，对特定癌症类型的影响在日本人群中也很弱。
The HOTAIR gene encodes a long noncoding RNA (IncRNA), which functions in development and tumorigenesis. A single nucleotide polymorphism (SNP) rs920778 in the HOTAIR gene, has been recurrently studied for susceptibility to many cancers including oesophageal cancer, gastric cancer, lung cancer, and hepatocellular carcinoma. Most of these studies were conducted in Chinese populations, and a few in Turkish, Iranian, and Portuguese populations. They mostly give rise to controversial results. It still remains largely unknown whether the cancer risk is conferred in a Japanese population. Here, we established an association study on the representative SNP rs920778, to examine its contribution to the presence of cancer in consecutive autopsy cases in the JG-SNP database. A total of 1373 subjects (mean age 80) including 827 cancer positive and 546 cancer negative subjects were analyzed. As a result, the occurrence of overall cancer was not associated with the rs920778 polymorphism (p > 0.05). For each cancer type, we did not find association except for lung cancer (p = 0.04) which was more likely a by-chance association after multiple testing. Our findings imply that rs920778 polymorphism does not affect total cancer presence and the effect on specific cancer types is also weak in the Japanese population.