Real-time functional magnetic resonance imaging neurofeedback in motor neurorehabilitation.
Real-time functional magnetic resonance imaging neurofeedback in motor neurorehabilitation.
复制标题
运动神经康复中的实时功能磁共振成像神经反馈。
DOI：
10.1097/wco.0000000000000340
复制
发表时间：
2016-08
影响因子：
4.8
通讯作者：
Turner DL
中科院分区：
文献类型：
--
作者：
Linden DE;Turner DL
功能磁共振成像(FMRI)的最新发展催生了翻译神经科学的一个新领域。使用功能磁共振成像来监测与任务相关的神经激活或大脑连接变化的方面，研究人员可以准实时地向参与者提供简单或复杂的神经信号/模式的反馈[基于实时功能磁共振成像的神经反馈(RT-fMRI-NF)]。在这里，我们介绍了这一领域新发展的一些背景方法学，并对它们未来如何用于神经康复进行了展望。RT-fMRI-NF的发展已被用于促进几个大脑区域和网络活动的自我调节。此外，与其他非侵入性技术不同，RT-fMRI-NF可以访问特定的皮质下区域，原则上可以访问任何可以使用fMRI进行监测的区域，包括小脑、脑干和脊髓。在帕金森氏症和中风中，RT-fMRI-NF已经被证明可以在自我调节训练完成后改变神经活动，并改变特定的行为。未来RT-fMRI-NF的开发可以用来诱导与某些神经疾病有关的大脑网络的神经可塑性。然而，目前，RT-fMRI-NF在随机对照临床试验中的应用还处于起步阶段。
Recent developments in functional magnetic resonance imaging (fMRI) have catalyzed a new field of translational neuroscience. Using fMRI to monitor the aspects of task-related changes in neural activation or brain connectivity, investigators can offer feedback of simple or complex neural signals/patterns back to the participant on a quasireal-time basis [real-time-fMRI-based neurofeedback (rt-fMRI-NF)]. Here, we introduce some background methodology of the new developments in this field and give a perspective on how they may be used in neurorehabilitation in the future. The development of rt-fMRI-NF has been used to promote self-regulation of activity in several brain regions and networks. In addition, and unlike other noninvasive techniques, rt-fMRI-NF can access specific subcortical regions and in principle any region that can be monitored using fMRI including the cerebellum, brainstem and spinal cord. In Parkinson's disease and stroke, rt-fMRI-NF has been demonstrated to alter neural activity after the self-regulation training was completed and to modify specific behaviours. Future exploitation of rt-fMRI-NF could be used to induce neuroplasticity in brain networks that are involved in certain neurological conditions. However, currently, the use of rt-fMRI-NF in randomized, controlled clinical trials is in its infancy.