Distribution of β2 microglobulin and HLA in chorionic villi of human placentae
Distribution of β2 microglobulin and HLA in chorionic villi of human placentae
复制标题
β2微球蛋白和HLA在人胎盘绒毛膜绒毛中的分布
作者：
W. Faulk;A. Temple
移植和胎盘免疫学之间经常有类比。组织相容性抗原的作用在移植免疫学中具有无可争议的重要性，但尚不清楚这些抗原在妊娠中是否重要。事实上，它是不知道是否滋养细胞表现组织相容性抗原。如果HLA抗原与妊娠有关，了解滋养层细胞是否具有这些抗原是至关重要的。这是一个难题，因为人抗HLA血清通常含有其他抗体，而异源抗HLA血清通常缺乏精确的HLA特异性1。但HLA已被证明总是与β2-微球蛋白2相关，在这里，我们提出的数据支持的概念，即人类滋养层细胞既不含β2-微球蛋白，也不含HLA。此外，用几种酶处理未能揭示这些抗原。此外，我们还不能在6周或13周胎盘的滋养层细胞或在体外维持5天的胎盘组织上鉴定β2微球蛋白或HLA。
ANALOGIES are often made between transplantation and placental immunology. The role of histocompatibility antigens is of undisputed importance in transplantation immunology but it is not clear whether such antigens are important in pregnancy. Indeed, it is not known whether trophoblasts manifest histocompatibility antigens. If HLA antigens are relevant in pregnancy, it is of central importance to know if trophoblasts have these antigens. This is a difficult problem because human anti-HLA sera often contain other antibodies, and heterologous anti-HLA sera often lack precise HLA specificity1. But HLA has been shown to be invariably associated with β2-microglobulin2, and here we present data in support of the concept that human trophoblasts contain neither β2 microglobulin nor HLA. Also, treatment with several enzymes has failed to reveal these antigens. In addition, we have not been able to identify either β2 microglobulin or HLA on trophoblasts from 6-week or 13-week placentae or on placental tissues maintained in vitro for 5 d.