Using synthetic chemistry to understand copper protein active sites: a personal perspective.
Using synthetic chemistry to understand copper protein active sites: a personal perspective.
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使用合成化学了解铜蛋白活性位点：个人观点。
DOI：
10.1007/s00775-006-0078-9
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发表时间：
2006
期刊：
影响因子：
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通讯作者：
Tolman,WilliamB
中科院分区：
文献类型：
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作者：
Tolman,WilliamB
在作者的实验室进行的研究的结果进行了调查，特别强调展示的价值，多学科的合成建模方法，发现新的和不寻常的化学有助于了解铜蛋白的活性位点的性质或评估的可行性，他们可能遵循的机制途径在催化过程中。重点讨论了亚硝酸还原酶的催化位点和机制、硫醇铜电子转移中心的电子结构、一氧化二氮还原酶中的硫桥“CuZ”位点以及氧化酶和加氧酶中单铜和双铜中心对分子氧结合和活化的过程。
The results of studies performed in the author’s laboratory are surveyed, with particular emphasis on demonstrating the value of a multidisciplinary synthetic modeling approach for discovering new and unusual chemistry helpful for understanding the properties of the active sites of copper proteins or assessing the feasibility of mechanistic pathways they might follow during catalysis. The discussion focuses on the progress made to date toward comprehending the nitrite reductase catalytic site and mechanism, the electronic structures of copper thiolate electron transfer centers, the sulfido-bridged “CuZ” site in nitrous oxide reductase, and the processes of dioxygen binding and activation by mono- and dicopper centers in oxidases and oxygenases.