The central role of the temporo-parietal junction and the superior longitudinal fasciculus in supporting multi-item competition: Evidence from lesion-symptom mapping of extinction
The central role of the temporo-parietal junction and the superior longitudinal fasciculus in supporting multi-item competition: Evidence from lesion-symptom mapping of extinction
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DOI：
10.1016/j.cortex.2011.11.008
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发表时间：
2013-02-01
期刊：
影响因子：
3.6
通讯作者：
Humphreys, Glyn W.
中科院分区：
文献类型：
--
作者：
Chechlacz, Magdalena;Rotshtein, Pia;Humphreys, Glyn W.
本研究探讨了视觉和触觉消失相关病变（VE和TB）与视野缺陷和空间忽视相关病变之间的关系。患者表现的持续变化被用来评估行为评分与灰质和白质（GM和WM）完整性之间的联系。我们发现了与消失和忽视相关的常见和独特的神经基质。枕角回、枕中回、颞上沟和脑岛的损伤与VE有关。涉及边缘上回（SMG）、顶叶内沟、额中回和颞上回（MFG和STG）的病变仅与空间忽视相关。影响颞顶交界处（TPJ）、颞中区、中额区（BA46）以及脑岛和壳核的病变与空间忽视和VE有关。分析VE和TB之间的关系，强调TPJ是两种方式的共同部位。这些发现表明，TPJ在识别多模态感觉环境中的显著事件方面起着普遍作用。此外，WM分析指出，上纵束是连接视觉空间注意网络各组成部分的关键。我们证明了SLF损伤导致的功能断开有助于改变注意力任务的表现，不仅测量忽视，还测量VE和TB。我们认为，SLF支持涉及多种感觉模式的注意控制的功能专门化区域之间的相互作用。(C) 2011 Elsevier Ltd.版权所有。
The present study examined the relations between the lesions linked to visual and tactile extinction (VE and TB), and those related to visual field defects and spatial neglect. Continuous variations in patients' performance were used to assess the link between behavioural scores and integrity of both grey and white matter (GM and WM). We found both common and distinct neural substrates associated with extinction and neglect. Damage to angular and middle occipital gyri, superior temporal sulcus (STS) and insula were linked to VE. Lesions involving the supramarginal gyrus (SMG), intraparietal sulcus, middle frontal and superior temporal gyri (MFG and STG) were associated exclusively with spatial neglect. Lesions affecting the temporo-parietal junction (TPJ), the middle temporal region, middle frontal area (BA46) as well as the insula and putamen were linked to both spatial neglect and VE. Analysis of the relations between VE and TB highlighted the TPJ as the common site for both modalities. These findings suggest that the TPJ plays a general role in identifying salient events in the sensory environment across multiple modalities. Furthermore, WM analyses pointed to superior longitudinal fasciculus (SLF) as critical for interconnecting components of the visuospatial attention network. We demonstrated that functional disconnections resulting from SLF damage contribute to altered performance on attention tasks measuring not only neglect but also VE and TB. We propose that the SLF supports interactions between functionally specialized regions involved in attentional control across multiple sensory modalities. (C) 2011 Elsevier Ltd. All rights reserved.