Supplementation with soy isoflavones alleviates depression-like behaviour via reshaping the gut microbiota structure.
Supplementation with soy isoflavones alleviates depression-like behaviour via reshaping the gut microbiota structure.
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DOI：
10.1039/d0fo03254a
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发表时间：
2021-06
期刊：
影响因子：
6.1
通讯作者：
Li Wang;Xue Wu;Yuhao Ma;Xian Li;Jingfeng Zhang;Lichao Zhao
中科院分区：
文献类型：
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作者：
Li Wang;Xue Wu;Yuhao Ma;Xian Li;Jingfeng Zhang;Lichao Zhao
大豆异黄酮（SI）因其在减轻神经退行性疾病中的有益作用而闻名，而SI减轻抑郁样行为的机制仍不清楚。本研究采用慢性不可预见性轻度应激（unpredictable mild stress，SIRS）诱导的抑郁大鼠模型，探讨SI对抑郁样行为的缓解作用及其可能机制。SI补充剂通过增加单胺神经递质水平显著改善了CNS诱导的抑郁样行为。特定的SI剂量显著调节肠道微生物群的组成，这反过来又提高了SI的最大生物转化能力。斯皮尔曼的相关性分析表明，一些肠道微生物群属与单胺神经递质密切相关。此外，应更多地关注性别差异，这可能与肠道微生物群的变化有关。这些结果表明，SI可能通过重塑肠道微生物群的结构来影响BNS大鼠的单胺神经递质，从而减轻抑郁样行为。
Soy isoflavones (SI) are known for their beneficial effects in alleviating neurodegenerative diseases, while the mechanism of alleviation of depression-like behaviour by SI remains unclear. In this study, a chronic unpredictable mild stress (CUMS)-induced depression rat model was used to determine the effect of SI in alleviating depression-like behaviour and its possible mechanisms. SI supplements significantly improved the CUMS-induced depression-like behaviour by increasing the monoamine neurotransmitter levels. A specific SI dose significantly modulated the composition of the gut microbiota, which in turn improved the maximum biotransformation ability of SI. Spearman's correlation analysis illustrated that some of the gut microbiota genera were strongly correlated with monoamine neurotransmitters. Moreover, more attention should be paid to gender differences, which may be related to changes in the gut microbiota. These results suggest that SI might affect monoamine neurotransmitters of CUMS rats by reshaping the structure of the gut microbiota, thereby alleviating depression-like behaviour.