HOMOLOGIES IN BOTH PRIMARY AND SECONDARY STRUCTURE BETWEEN NUCLEAR-ENVELOPE AND INTERMEDIATE FILAMENT PROTEINS
HOMOLOGIES IN BOTH PRIMARY AND SECONDARY STRUCTURE BETWEEN NUCLEAR-ENVELOPE AND INTERMEDIATE FILAMENT PROTEINS
复制标题
DOI：
10.1038/319463a0
复制
发表时间：
1986-02-06
期刊：
影响因子：
64.8
通讯作者：
CAPUT, D
中科院分区：
文献类型：
--
作者：
MCKEON, FD;KIRSCHNER, MW;CAPUT, D
A、B和C层是核膜的主要蛋白质。A和C层蛋白编码区的完整核苷酸序列表明，除了它们的羧基末端外，这些蛋白质是相同的。两层膜最显著的结构特征是α。氨基酸重复七体的螺旋区域，与细胞质中间丝蛋白的整个家族具有惊人的同源性。这些特征表明，核膜是由一个网状的线圈状聚合物组成的。
The A, B and C lamins are the major proteins of the nuclear envelope. The complete nucleotide sequence of the coding region of the A and C lamins shows that these proteins are identical except for their carboxy termini. The most prominent structural feature of both lamins is an .alpha.-helical region of repeating heptads of amino acids that shows striking homology with the entire family of cytoplasmic intermediate filament proteins. These features suggest that the nuclear envelope is made up of a network of coiled-coil polymers.