Immune Regulation and Antitumor Effect of TIM-1.
Immune Regulation and Antitumor Effect of TIM-1.
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DOI：
10.1155/2016/8605134
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发表时间：
2016
影响因子：
4.1
通讯作者：
Jiang J
中科院分区：
文献类型：
--
作者：
Du P;Xiong R;Li X;Jiang J
T细胞在抗肿瘤免疫中起着重要作用，T细胞免疫球蛋白结构域及其表面的粘蛋白结构域蛋白-1（TIM-1）作为共刺激分子，对T细胞具有较强的调节作用。TIM-1可以调节和增强肿瘤相关的1型免疫应答。因此，TIM-1共刺激通路可能是未来肿瘤免疫治疗的一个有希望的治疗靶点。本文就TIM-1的免疫调节和抗肿瘤作用作一综述。
T cells play an important role in antitumor immunity, and the T cell immunoglobulin domain and the mucin domain protein-1 (TIM-1) on its surface, as a costimulatory molecule, has a strong regulatory effect on T cells. TIM-1 can regulate and enhance type 1 immune response of tumor association. Therefore, TIM-1 costimulatory pathways may be a promising therapeutic target in future tumor immunotherapy. This review describes the immune regulation and antitumor effect of TIM-1.