Regional-scale investigation for microbial competition -through-environment interactions modulating antibiotic resistance
Regional-scale investigation for microbial competition -through-environment interactions modulating antibiotic resistance
复制标题
通过环境相互作用调节抗生素耐药性的微生物竞争的区域规模调查
DOI：
10.1016/j.scitotenv.2020.139341
复制
发表时间：
2020
影响因子：
9.8
通讯作者：
Zhao Haiyan
中科院分区：
文献类型：
--
作者：
Wang Qian;Hamilton Paul B.;Kang Fuxing;Zhu Xuezhu;Zhang Yiting;Zhao Haiyan
抗生素耐药性源于微生物之间长期的竞争，是一个严重的全球健康问题。为了避免抗生素耐药性的风险，全世界都在限制抗生素的消费方面付出了巨大的努力，但迄今为止收效甚微。阻力受到自然和人为来源的多重压力的控制，这进一步造成了控制问题。本研究确定了中国1000公里长的长江流域42个湖泊群表层沉积物中从抗生素抗性基因（ARG）到微生物群落再到环境压力的一系列联系，并试图阐述这种抗性风险的控制途径。结果表明，670个细菌家族中有11个可分为相互拮抗的抗生素耐药或非耐药群落。在自然系统中，拮抗竞争控制着 ARG 的增加和减少。抗生素抗性菌株的优越性引发了与耐药性风险普遍相关的微生物多样性的丧失。这项研究表明，抗生素通过定向子的非线性作用塑造抗性群落中 ARG 的进化；其他选定的压力通过研究的链接链充当增强抗生素耐药性的促进剂。此外，根据分类群落的耐受性，从七十个湖泊参数中确定并选择了通过温度、盐度和镁的自然发育进行研究。对选定压力的线性反馈使非耐药菌群在竞争中胜过耐药菌群，理论上调节了抗生素耐药性的风险。
Originating from a long history of competition between microbes, antibiotic resistance is a serious global health concern. To avoid the risk of antibiotic resistance, tremendous efforts have been directed towards restricting antibiotic consumption worldwide, but to date with limited success. Resistance is governed by multiple pressures from natural and anthropogenic origins which further create problems with control. This study identifies a chain of links from antibiotic resistant genes (ARGs) to microbial communities to environmental pressures in the surface sediments of forty-two lake clusters across the 1000-km Yangtze Basin of China, and attempts to expound on a control pathway for this resistance risk. Results show that eleven of the 670 bacterial families can be classified as antibiotic-resistant or nonresistant communities which antagonize each other. In natural systems, antagonistic competition controls the increase and decrease in ARGs. Superiority of antibiotic-resistant strains initiates a loss in microbial diversity associated with the prevalence of resistance risk. This study shows that, antibiotics shape the evolution of ARGs in resistant communities through a nonlinear role of orientor; other selected pressures serve as a facilitator to enhance the antibiotic resistance through an investigated chain of links. Furthermore, according to tolerances of the classified communities, abiogenetic development through temperature, salinity and Mg were identified and selected for study from seventy lake parameters. Linear feedbacks to selected pressures make the nonresistant communities outcompete the resistant communities, theoretically modulating the risk of antibiotic resistance.