Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats.
Corticotropin-releasing factor mediates the dysphoria-like state associated with alcohol withdrawal in rats.
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DOI：
10.1016/j.bbr.2010.02.043
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发表时间：
2010-07-11
影响因子：
2.7
通讯作者：
Yamada, Hidetaka
中科院分区：
文献类型：
--
作者：
Bruijnzeel, Adrie W.;Small, Elysia;Pasek, Tim M.;Yamada, Hidetaka
This study investigated the role of CRF in the dysphoria-like state associated with alcohol withdrawal in rats. The intracranial self-stimulation procedure was used to assess brain reward thresholds. Cessation of chronic alcohol administration lead to an elevation in brain reward thresholds in the alcohol dependent rats. The CRF receptor antagonist D-Phe CRF(12-41) dose-dependently prevented the elevations in brain reward thresholds associated with alcohol withdrawal. This indicates that the dysphoria associated with alcohol withdrawal is at least partly mediated by the activation of central CRF receptors.
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影响因子：
168.9
作者：
Hall, W;Zador, D
通讯作者：
Zador, D
影响因子：
2.9
作者：
RASSNICK, S;HEINRICHS, SC;KOOB, GF
通讯作者：
KOOB, GF
影响因子：
4.7
作者：
Zislis, George;Desai, Tina V.;Bruijnzeel, Adrie W.
通讯作者：
Bruijnzeel, Adrie W.
影响因子：
3.4
作者：
Rylkova, Daria;Shah, Hina P.;Small, Elysia;Bruijnzeel, Adrie W.
通讯作者：
Bruijnzeel, Adrie W.
影响因子：
7.6
作者：
Bruijnzeel, Adrie W.;Zislis, George;Gold, Mark S.
通讯作者：
Gold, Mark S.