Investigating the Clough, Lutz, and Jirgensons Rule for the pH Dependence of Optical Rotation of Amino Acids
Investigating the Clough, Lutz, and Jirgensons Rule for the pH Dependence of Optical Rotation of Amino Acids
复制标题
研究氨基酸旋光度 pH 依赖性的 Clough、Lutz 和 Jirgensons 规则
DOI：
--
复制
发表时间：
2018
影响因子：
3
通讯作者：
Alexandra M. Izydorczak
中科院分区：
文献类型：
--
作者：
S. Simpson;Alexandra M. Izydorczak
一门高级物理化学课程的学生使用旋光仪测量不同光学活性氨基酸的摩尔旋光度，以确认Clough，Lutz和Jirgensons(CLJ)规则。这一规则指出，如果加酸后摩尔旋光度变得更正，则氨基酸为L构型；如果在酸化溶液中，旋光度变得更负，氨基酸为d构型。学生们演示了已知氨基酸构型的这一规则，然后应用这一规则来确定具有未知构型的氨基酸的构型。
Students in an upper-level physical chemistry course used a polarimeter to measure the molar optical rotation of different optically active amino acids to confirm the Clough, Lutz, and Jirgensons (CLJ) rule. This rule states that an amino acid is in the l-configuration if the molar optical rotation becomes more positive upon the addition of acid or the acid is of the d-configuration if the optical rotation becomes more negative in an acidified solution. Students demonstrated this rule for known configurations of amino acids and then applied this rule to determine the configuration of an amino acid with an unknown configuration.