Functional cell types in the mouse superior colliculus.
Functional cell types in the mouse superior colliculus.
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DOI：
10.7554/elife.82367
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发表时间：
2023-04-19
期刊：
影响因子：
7.7
通讯作者：
Meister M
中科院分区：
文献类型：
--
作者：
Li YT;Meister M
上级丘（SC）代表哺乳动物大脑中的主要视觉处理站，其接收来自多种类型的视网膜神经节细胞（RGC）的输入。SC中存在多少个并行通道，每个通道编码什么信息？在这里，我们记录了小鼠浅表SC神经元下的电池的视觉刺激，包括用于分类的RGCs。一种无监督聚类算法根据视觉反应识别了24种功能类型。他们分为两组：一组对RGC的反应相似，另一组具有更多样化和专业化的刺激选择性。第二组是占主导地位的更大的深度，在SC中的信号处理的垂直进展一致。相同功能类型的细胞往往群集在解剖空间彼此附近。与视网膜相比，SC中的视觉表征具有较低的维度，与沿着视觉通路的筛选过程一致。
The superior colliculus (SC) represents a major visual processing station in the mammalian brain that receives input from many types of retinal ganglion cells (RGCs). How many parallel channels exist in the SC, and what information does each encode? Here, we recorded from mouse superficial SC neurons under a battery of visual stimuli including those used for classification of RGCs. An unsupervised clustering algorithm identified 24 functional types based on their visual responses. They fall into two groups: one that responds similarly to RGCs and another with more diverse and specialized stimulus selectivity. The second group is dominant at greater depths, consistent with a vertical progression of signal processing in the SC. Cells of the same functional type tend to cluster near each other in anatomical space. Compared to the retina, the visual representation in the SC has lower dimensionality, consistent with a sifting process along the visual pathway.