EXOGENOUS SEX-HORMONES AND THE RISK OF RHEUMATOID-ARTHRITIS
EXOGENOUS SEX-HORMONES AND THE RISK OF RHEUMATOID-ARTHRITIS
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DOI：
10.1002/art.1780330705
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发表时间：
1990-07-01
影响因子：
--
通讯作者：
SPEIZER, FE
中科院分区：
文献类型：
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作者：
HERNANDEZAVILA, M;LIANG, MH;SPEIZER, FE
自1976年以来，在护士的健康研究中，使用了与类风湿关节炎（RA）的风险相关的外源性激素（RA）的使用。 1976年获得了有关口服避孕药，替代雌激素和其他潜在危险因素使用的基线信息，并每2年更新一次。在7年的随访期间，确定了217例多重关节炎的事件（115 RA和102个未分化的多关节炎）。与从未使用过口服避孕药的女性相比，过去用户的年龄调整后的相对风险为1.0（95％置信区间[CI] 0.7-1.3）；但是，目前使用口服避孕药的妇女对其作用的可靠估计很少。在绝经后妇女中，有123例RA病例。与从未使用过替代雌激素的绝经后妇女相比，当前用户的相对风险为1.3（95％CI 0.9-2.0），过去的用户的相对风险为0.7（95％CI 0.5-1.2），，，95％CI 0.5-1.2），，95％并且用户的相对风险为1.0（95％CI 0.7-1.4）。这些数据没有显示出用于RA的口服避孕药或替代雌激素的保护作用；但是，不能排除当前口服避孕药的适度保护作用。
The use of exogenous sex hormones in relation to the risk of rheumatoid arthritis (RA) was examined in a cohort of married nurses 30-55 years of age followed since 1976 in the Nurses'' Health Study. Baseline information on the use of oral contraceptives, replacement estrogens, and other potential risk factors was obtained in 1976 and updated every 2 years. During 7 years of followup, 217 incident cases of polyarthritis were ascertained (115 RA and 102 undifferentiated polyarthritis). When compared with women who had never used oral contraceptives, the age-adjusted relative risk was 1.0 (95% confidence interval [CI] 0.7-1.3) for past users; however, too few women were currently using oral contraceptives for a reliable estimate of its effect. Among postmenopausal women, 123 cases of RA were reported. Compared with postmenopausal women who never used replacement estrogens, current users had an age-adjusted relative risk of 1.3 (95% CI 0.9-2.0), past users had an age-adjusted relative risk of 0.7 (95% CI 0.5-1.2), and ever users had a relative risk of 1.0 (95% CI 0.7-1.4). These data do not show a protective effect of past use of oral contraceptives or replacement estrogens for RA; however, a modest protective effect of current oral contraceptive use cannot be excluded.