Modulation of cell cycle regulators by HDACs.
Modulation of cell cycle regulators by HDACs.
复制标题
DOI：
10.2741/s303
复制
发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Seto E
中科院分区：
文献类型：
--
作者：
Telles E;Seto E
Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues on histones and non-histone proteins. HDACs have been shown to control the functions of key cell cycle proteins. Consistent with this, the overexpression of HDACs has been observed in multiple cancers, resulting in deregulation of the cell cycle and uncontrolled proliferation. This review focuses on the impact that HDACs have on cell cycle control through the deacetylation of proteins.
