Mammalian TOR: A homeostatic ATP sensor
Mammalian TOR: A homeostatic ATP sensor
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DOI：
10.1126/science.1063518
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发表时间：
2001-11-02
期刊：
影响因子：
56.9
通讯作者：
Thomas, G
中科院分区：
文献类型：
--
作者：
Dennis, PB;Jaeschke, A;Thomas, G
细菌大环内酯雷帕霉素是一种有效的抗癌剂对实体瘤。在低氧环境中，实体瘤质量的增加依赖于有丝分裂原和营养素的募集。当营养浓度变化时，特别是必需氨基酸的浓度变化时，哺乳动物雷帕霉素靶蛋白（mTOR）在控制核糖体生物合成和细胞生长的调节途径中发挥作用。在细菌中，核糖体的生物合成是由氨基酸和三磷酸腺苷（ATP）独立调节的。在这里，我们证明了mTOR通路受细胞内ATP浓度的影响，独立于氨基酸的丰度，并且mTOR本身是ATP传感器。
The bacterial macrolide rapamycin is an efficacious anticancer agent against solid tumors. In a hypoxic environment, the increase in mass of solid tumors is dependent on the recruitment of mitogens and nutrients. When nutrient concentrations change, particularly those of essential amino acids, the mammalian Target of Rapamycin (mTOR) functions in regulatory pathways that control ribosome biogenesis and cell growth. In bacteria, ribosome biogenesis is independently regulated by amino acids and adenosine triphosphate (ATP). Here we demonstrate that the mTOR pathway is influenced by the intracellular concentration of ATP, independent of the abundance of amino acids, and that mTOR itself is an ATP sensor.