Identity of HeLa cell determinants acquired by vesicular stomatitis virus with a tumor antigen.
Identity of HeLa cell determinants acquired by vesicular stomatitis virus with a tumor antigen.
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水泡性口炎病毒与肿瘤抗原获得的 HeLa 细胞决定簇的同一性。
DOI：
10.1126/science.6302845
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Huang,AS
中科院分区：
文献类型：
--
作者：
Little,LM;Zavada,J;Der,CJ;Huang,AS
水泡性口炎病毒（VSV）在HeLa细胞中的生长导致后代含有分子量约为75，000的非VSV抗原。用抗HeLa细胞决定簇的抗血清检测非VSV抗原。这些抗血清沉淀整个病毒粒子，但不能中和它们。因为其中一种抗血清针对HeLa细胞的肿瘤特异性表面抗原，所以似乎VSV在其通过人肿瘤细胞的过程中特异性地获得这些抗原。
Growth of vesicular stomatitis virus (VSV) in HeLa cells results in progeny containing non-VSV antigens with a molecular weight around 75,000. The non-VSV antigens were detected by antiserums to HeLa cell determinants. These antiserums precipitate whole virions but do not neutralize them. Because one of the antiserums is directed to a tumor-specific surface antigen of HeLa cells, it appears that VSV specifically acquires such antigens during its passage through human tumor cells.