CENTRAL-NERVOUS-SYSTEM TOXICITY OF LOCAL-ANESTHETIC MIXTURES IN MONKEYS
CENTRAL-NERVOUS-SYSTEM TOXICITY OF LOCAL-ANESTHETIC MIXTURES IN MONKEYS
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DOI：
10.1097/00000542-197703000-00004
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发表时间：
1977-01-01
期刊：
影响因子：
8.8
通讯作者：
EMBRO, WJ
中科院分区：
文献类型：
--
作者：
MUNSON, ES;PAUL, WL;EMBRO, WJ
评价了4只健康、未给药恒河猴[Macaca mulatta]静脉注射由利多卡因和依替卡因或利多卡因和丁卡因组成的局部麻醉剂混合物的CNS毒性。通过确定每种药物单独使用以及利多卡因-依替卡因或利多卡因-丁卡因混合物的癫痫发作剂量来比较毒性。动脉血浆水平的利多卡因和依替多卡因的电发作活动发生时，也进行了测量时，药物单独和联合给药。癫痫发作的剂量和动脉血浆水平的药物混合物的研究是等于剂量和阈值的总和的混合物的个别成分。在本研究条件下，局部麻醉剂毒性是累加的。
The CNS toxicities of local anesthetic mixtures consisting of lidocaine and etidocaine or lidocaine and tetracaine, administered i.v. to 4 healthy, nonmedicated rhesus monkeys [Macaca mulatta], were evaluated. Toxicities were compared by determining seizure dosages for each drug alone and then in a lidocaine-etidocaine or lidocaine-tetracaine mixture. Arterial plasma levels of lidocaine and etidocaine at which electrical seizure activity occurred also were measured when the drugs were administered alone and in combination. The seizure dosages and arterial plasma levels for the drug mixtures studied were equal to the sums of the dosages and thresholds for individual constituents of the mixtures. Under the conditions of this investigation local anesthetic toxicity was additive.