Bioconjugated quantum rods as targeted probes for efficient transmigration across an in vitro blood-brain barrier
Bioconjugated quantum rods as targeted probes for efficient transmigration across an in vitro blood-brain barrier
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DOI：
10.1021/bc700477u
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发表时间：
2008-06-01
影响因子：
4.7
通讯作者：
Prasad, Paras N.
中科院分区：
文献类型：
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作者：
Xu, Gaixia;Yong, Ken-Tye;Prasad, Paras N.
我们在这里报告，我们认为这是第一次，成功的运输生物共轭量子棒（QR）通过受体介导的运输在体外血脑屏障（BBB）模型，以及使用QR多路复用技术，同时比较不同的生物分子穿越血脑屏障的迁移效率。发现生物缀合的QR穿过体外血脑屏障的迁移率具有浓度和时间依赖性。这项工作说明了一个基于纳米颗粒的平台，不仅可以直接可视化各种生物分子穿过BBB的迁移能力，而且还可以促进新型诊断和治疗纳米探针的开发，用于早期诊断和治疗全身给药后的各种脑部疾病。
We report here, what we believe to be the first time, the successful transport of bioconjugated quantum rods (QRs) across an in vitro blood-brain barrier (BBB) model via a receptor-mediated transport, as well as the use of QR multiplexing technique to compare simultaneously the transmigration efficiency of different biomolecules across the BBB. The migration rate of bioconjugated QRs crossing the in vitro BBB was found to be concentration and time-dependent. This work illustrates a nanoparticle-based platform that Will not only allow a direct visualization of the transmigration ability of various kinds of biomolecules across the BBB, but also facilitate the development of novel diagnostic and therapeutic nanoprobes for early diagnosis and therapy of various disorders of the brain following systemic administration.