Measurement of distress and its alteration during treatment in patients with nasopharyngeal carcinoma
Measurement of distress and its alteration during treatment in patients with nasopharyngeal carcinoma
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鼻咽癌患者治疗过程中痛苦的测量及其变化
DOI：
10.1002/hed.23412
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发表时间：
2014-08-01
影响因子：
2.9
通讯作者：
Jiang, Yu
中科院分区：
文献类型：
--
作者：
Deng, Yao-Tiao;Zhong, Wu-Ning;Jiang, Yu
背景我们检验了痛苦温度计（DT）筛查鼻咽癌（NPC）患者痛苦的标准相关效度，并前瞻性地调查了痛苦的变化。在横断面研究中，DT与医院焦虑和抑郁量表（HADS）在295例NPC患者中进行了测试。在前瞻性研究中，61例初诊鼻咽癌患者完成了6次DT和HADS。以HADS作为抑郁筛查标准，31.5%的鼻咽癌患者有抑郁症状。DT临界评分>= 4具有最佳敏感性（0.73）和特异性（0.85）。在前瞻性研究中，治疗期间患者的痛苦比例显著上升。受试者工作特征（ROC）的结果提供了初步的支持DT在NPC患者中的有效性。在横断面研究中，近三分之一的NPC患者超过了痛苦的临界值。在前瞻性研究中，鼻咽癌患者在同步放化疗期间的痛苦水平显著增加。(C)2014年威利期刊公司
Background. We examined the criterion-related validity of the Distress Thermometer (DT) for screening distress in patients with nasopharyngeal carcinoma (NPC) and investigated prospectively how distress changes.Methods. In the cross-sectional study, the DT was tested against the Hospital Anxiety and Depression Scale (HADS) in 295 patients with NPC. In the prospective study, 61 newly diagnosed patients with NPC completed the DT and HADS 6 times.Results. Adopting HADS as the standard tool for screening distress, 31.5% of the patients with NPC had distress. A DT cutoff score >= 4 had best sensitivity (0.73) and specificity (0.85). In the prospective study, the proportion of patients with distress rose significantly during treatment.Conclusion. Receiver operating characteristic (ROC) findings provide initial support for the validity of the DT among patients with NPC. Nearly one third of patients with NPC exceeded cutoff values for distress in the cross-sectional study. In the prospective study, the level of distress increased significantly during concurrent chemoradiotherapy for patients with NPC. (C) 2014 Wiley Periodicals, Inc.