Is carbon dioxide (CO2) a useful short acting anaesthetic for small laboratory animals?
Is carbon dioxide (CO2) a useful short acting anaesthetic for small laboratory animals?
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DOI：
10.1258/002367799780578390
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发表时间：
1999-04-01
影响因子：
2.4
通讯作者：
Schatzmann, U
中科院分区：
文献类型：
--
作者：
Kohler, I;Meier, R;Schatzmann, U
在大鼠、小鼠和豚鼠上，分别用氧气浓度为20%的混合气体(O-2)和空气浓度为20%的混合气体，在规定的暴露时间内观察二氧化碳的麻醉效果。大鼠的首发症状(中位数)出现在7~9.5 S之间，诱导时间(中位数)在16~20.5 S之间，对80%CO_2/20%O~(-2)的手术耐受率(中位数)分别为40 S(60 S后)和53.5 S(120 S后)。当用环境空气代替氧气时，测得的手术耐受S(S 60次)为53.5%，S(S 120次)为77次。小鼠对80%CO_2/20%O_2的诱导时间为10个S，手术耐受时间为19.5个S(暴露后120个S)。豚鼠对80%CO_2/O~(-2)的诱导期为20~S，手术耐受期为50~S(暴露30~S后)。在所有物种中，复苏都是欢呼雀跃和顺利的。这种全身麻醉方法似乎适用于短时间和痛苦的干预，主要是在大鼠身上，但也适用于豚鼠。
The anaesthetic effect of carbon dioxide (CO2) was investigated under predetermined exposure times in rats, mice and guineapigs with admixture of 20% of oxygen (O-2), and with 20% of ambient air in rats. In rats first symptoms (median) were detectable between 7 and 9.5 s, the induction time (median) varied between 16 and 20.5 s and the surgical tolerance (median) was 40 s lafter 60 s of exposure) and 53.5 s (after 120 s of exposure) to 80% CO2/20% O-2. When O-2 was replaced by ambient air, a surgical tolerance of 53.5 s (after 60 s of exposure) and 77 s (after 120 s of exposure) was measured. In mice the induction time to 80% CO2/20% O-2 was 10 s and the surgical tolerance 19.5 s (after 120 s of exposure). Guineapigs showed an induction period of 20 s and a surgical tolerance of 50 s (after 30 s of exposure) to 80% CO2/O-2. Recovery was shout and smooth in all species. This method of general anaesthesia seems to be suitable for short and painful interventions, mainly in rats, but also in guineapigs.