Insights into the structure and function of GABA-benzodiazepine receptors: ion channels and psychiatry.
Insights into the structure and function of GABA-benzodiazepine receptors: ion channels and psychiatry.
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深入了解 GABA-苯二氮卓受体的结构和功能：离子通道和精神病学。
DOI：
10.1176/ajp.148.2.162
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Isenberg,KE
中科院分区：
文献类型：
--
作者：
Zorumski,CF;Isenberg,KE
γ-氨基丁酸（γ-aminobutyric acid，GABA）受体是γ-氨基丁酸（γ-aminobutyric acid，GABA）受体的一个重要组成部分。这些见解有助于确定GABA受体在突触抑制中的作用，以及不同神经精神药物发挥作用的离子通道机制。作者的目标是描述GABA作为一种神经递质的行动，并讨论调制受体功能的不同drugs.Data collectionTheauthors专注于最近的研究的结构和生理学的受体离子通道复合物和这些研究的相关性精神病学。FindingsThe中枢神经系统的影响苯二氮卓类药物，巴比妥类药物，酒精已被链接到GABA-氯离子通道受体复合物。该复合物的多个亚基已被克隆、测序并在异源系统中表达。克隆研究的结果，再加上膜生物物理学，提供了重要的见解GABA受体的结构和功能和他们的modulation由psychopharmacological agents.ConclusionsFuture了解疾病状态，药物的影响，和治疗的成功和失败可能会表示在特定受体及其相关的离子通道的结构和功能的差异。此外，描述受体亚型的分子功能的能力提供了通过开发针对给定受体亚型的药剂来定制药物特异性的能力。目前的GABA研究也对理解神经递质系统如何参与疾病具有重要意义。
ObjectiveAs a result ofcombmned biophysical and molecular biological studies, important insights into the structure and function of y-aminobutyric acid (GABA) receptors have been achieved. These insights have helped to define the role of GABA receptors in synaptic inhibition and the ion channel mechanisms by which different neuropsychiatric drugs work. The authors’ goal is to describe the actions of GABA as a neurotransmitter and discuss the modulation of receptor function by different drugs.Data collectionThe authors focus on more recent studies of the structure and physiology of the receptor-ion channel complex and the relevance of these studies to psychiatry.FindingsThe CNS effects of benzodiazepines, barbiturates, and alcohol have been linked to the GABA-chloride channel receptor complex. Multiple subunits of this complex have been cloned, sequenced, and expressed in heterologous systems. The results of cloning studies, coupled with membrane biophysics, have provided important insights into the structure and function of GABA receptors and their mod-ulation by psychopharmacological agents.ConclusionsFuture understanding of disease states, drug effects, and therapeutic successes and failures may be expressed in terms of differences in the structure and function of specific receptors and their associated ion chan-nels. Furthermore, the ability to describe the molecular function of receptor subtypes offers the ability to tailor drug specificity by developing agents directed against a given receptor subtype. The current GABA studies also have important implications for the understanding of how neurotransmitter systems may be involved in illness.