Coffee and tea consumption in relation to estimated glomerular filtration rate: results from the population-based longitudinal Doetinchem Cohort Study
Coffee and tea consumption in relation to estimated glomerular filtration rate: results from the population-based longitudinal Doetinchem Cohort Study
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DOI：
10.3945/ajcn.115.112755
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发表时间：
2016-05-01
影响因子：
7.1
通讯作者：
Spijkerman, Annemieke M. W.
中科院分区：
文献类型：
--
作者：
Herber-Gast, Gerrie-Cor M.;van Essen, Hanneke;Spijkerman, Annemieke M. W.
背景：尽管咖啡摄入和茶摄入与糖尿病有关，但它们与肾功能的关系不太明确且研究不足。
目的：我们研究了咖啡和茶的摄入与估算肾小球滤过率（eGFR）之间的前瞻性关联。
设计：我们纳入了来自多廷赫姆队列研究的4722名年龄在26 - 65岁的参与者，对他们每5年进行一次检查，共持续15年。在每一轮检查中评估咖啡和茶的摄入量（以杯/天为单位）。使用基于血浆肌酐和胱抑素C的慢性肾脏病流行病学协作公式评估eGFR。我们通过广义估计方程分析确定了咖啡和茶摄入类别与以下两者之间的关联：1）eGFR；2）eGFR随后的年度变化。
结果：基线平均±标准差eGFR为108.0 ± 14.7毫升·分钟⁻¹·1.73平方米⁻²。茶的摄入与eGFR无关。那些每天饮用＞6杯咖啡的个体比每天饮用≤2杯咖啡的个体的eGFR高1.33（95%置信区间：0.24，2.43）毫升·分钟⁻¹·1.73平方米⁻²。在年龄＜46岁的参与者中，这种关联更强（每天饮用＞6杯咖啡与≤2杯咖啡相比，eGFR差异为2.28（95%置信区间：0.68，3.88）毫升·分钟⁻¹·1.73平方米⁻²）。咖啡摄入与eGFR变化无关，这表明咖啡饮用者中较高的eGFR不太可能是肾小球高滤过的结果。因此，对于一般人群来说，低至中等量的咖啡摄入预计不会对肾脏健康造成影响。
Background: Although coffee consumption and tea consumption have been linked to diabetes, the relation with kidney function is less clear and is underresearched.Objective: We investigated the prospective associations of coffee and tea consumption with estimated glomerular filtration rate (eGFR).Design: We included 4722 participants aged 26-65 y from the Doetinchem Cohort Study who were examined every 5 y for 15 y. Coffee and tea consumption (in cups/d) were assessed at each round. eGFR was assessed by using the Chronic Kidney Disease Epidemiology Collaboration equation based on both plasma creatinine and cystatin C. We determined the association between categories of coffee and tea intake and 1) eGFR and 2) subsequent annual changes in eGFR by using generalized estimating equation analyses.Results: Baseline mean +/- SD eGFR was 108.0 +/- 14.7 mL . min(-1) 1.73 m(-2). Tea consumption was not associated with eGFR. Those individuals who drank >6 cups coffee/d had a 1.33 (95% CI: 0.24, 2.43) mL . min(-1) . 1.73 m(-2) higher eGFR than those who drank 6 cups/d compared with = 46 y. The absence of an association with eGFR changes suggests that the higher eGFR among coffee consumers is unlikely to be a result of glomerular hyperfiltration. Therefore, low to moderate coffee consumption is not expected to be a concern for kidney health in the general population.