Effect of grape seed extract on lead induced hypertension and heart rate in rat.
Effect of grape seed extract on lead induced hypertension and heart rate in rat.
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DOI：
10.3923/pjbs.2008.882.887
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发表时间：
2008-03-15
期刊：
影响因子：
--
通讯作者：
Dianat, Mahin
中科院分区：
文献类型：
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作者：
Badavi, Mohammad;Mehrgerdi, Fatemeh Zarea;Dianat, Mahin
本研究的主要目的是评估红葡萄籽提取物 (GSE) 对雄性 Wistar 大鼠铅诱导的高血压 (HTN) 和心率 (HR) 的潜在保护作用。将大鼠随机分配到4组中的一组：每组接受醋酸铅（饮用水中100 ppm）、GSE（100 mg kg(-1)，口服）或铅+GSE，为期45天。另一组被指定为对照组，提供自来水和普通颗粒食品。收缩压（SBP）和心率通过与计算机系统连接的尾部体积描记法测定。铅暴露大鼠的 SBP 持续升高，并在第 18 天显着升高（铅治疗组为 112.7 +/- 2.7 mmHg，对比对照组为 105.6 +/- 2.6 mmHg，n = 10，p < 0.05），并在第 36 天达到最高水平（铅治疗组为 124.9 +/- 2.3 mmHg，对比对照组为 103.6 +/- 2.6 mmHg） 3.1 毫米汞柱，n = 10，p < 0.001）。然而，其他三组；未显示 SBP 发生显着变化。此外，铅暴露动物的心率持续增加，在第 36 天和第 45 天具有统计学意义（铅治疗组，404.5 +/- 9.4 对比对照组，381.7 +/- 6.7，n = 10，p < 0.05）。与对照组和 GSE 治疗组相比，铅和铅 + GSE 治疗组的血铅水平均显着升高 (p < 0.001)。然而，GSE 给药对铅治疗组的血铅水平没有影响。根据这项研究的结果，可以得出结论，GSE 可以通过其抗氧化应激的抗氧化活性，对保护心血管系统产生有益的作用。
The main objective of this study was to evaluate the potential protective effect of red Grape Seed Extract (GSE) on lead induced hypertension (HTN) and Heart Rate (HR) in male Wistar rats. The rats were randomly assigned to one of 4 groups: Each group received lead acetate (100 ppm in drinking water), GSE (100 mg kg(-1), orally) or Lead + GSE for 45 days. Another group assigned as control group provided with tap water and regular pellet food. The Systolic Blood Pressure (SBP) and heart rate were determined by tail plethysmography coupled to a computer system. There was a sustained elevation of SBP in lead exposed rats that significantly increased at day 18 (lead treated, 112.7 +/- 2.7 mmHg, vs. control, 105.6 +/- 2.6 mmHg, n = 10, p < 0.05) and reached a maximum level at day 36 (lead treated, 124.9 +/- 2.3 mmHg, vs. control, 103.6 +/- 3.1 mmHg, n = 10, p < 0.001). However, the other three groups; showed no significant changes in SBP. Furthermore, the heart rate was increased sustainly in lead exposed animals that was statistically significant at days 36 and 45 (lead treated group, 404.5 +/- 9.4 vs. control group, 381.7 +/- 6.7, n = 10, p < 0.05). The blood lead level in both lead and lead + GSE treated groups was increased significantly compared with control and GSE treated groups (p < 0.001). However, GSE administration had no effect on the blood lead level in lead treated group. According to the result of this study, it may be concluded that GSE could have beneficial effect in protecting the cardiovascular system through its antioxidant activity against oxidative stress.