Actinomycin D: Suppression of Recovery in X-Irradiated Mammalian Cells
Actinomycin D: Suppression of Recovery in X-Irradiated Mammalian Cells
复制标题
放线菌素 D：抑制 X 射线照射的哺乳动物细胞的恢复
DOI：
10.1126/science.143.3613.1454
复制
发表时间：
1964
期刊：
影响因子：
56.9
通讯作者：
T. Alescio
中科院分区：
文献类型：
--
作者：
M. Elkind;G. Whitmore;T. Alescio
如果在两个剂量之间将培养细胞暴露在放线菌素D中，则两个X射线剂量的致死效应可以显著增强。净存活率可以通过温度和放线菌素处理来改变。这些效应与亚致死性损伤的修复和不同剂量之间的细胞动力学有关。
The lethal effect of two x-ray doses can be considerably enhanced if cultured cells are exposed to actinomycin D between doses. Net survival can be modified by temperature as well as actinomycin treatment. These effects are related to repair of sublethal damage and to cell kinetics between doses.