Carotid stiffness is associated with impairment of cognitive performance in individuals with and without type 2 diabetes. The Maastricht Study
Carotid stiffness is associated with impairment of cognitive performance in individuals with and without type 2 diabetes. The Maastricht Study
复制标题
DOI：
10.1016/j.atherosclerosis.2016.07.912
复制
发表时间：
2016-10-01
期刊：
影响因子：
5.3
通讯作者：
Stehouwer, Coen D. A.
中科院分区：
文献类型：
--
作者：
Geijselaers, Stefan L. C.;Sep, Simone J. S.;Stehouwer, Coen D. A.
背景和目的：越来越多的证据表明，动脉(主要是主动脉)僵硬和2型糖尿病(动脉僵硬的一个危险因素)与认知障碍和痴呆有关。然而，关于颈动脉僵硬的数据很少，这可能是特别相关的认知表现，很少有研究涉及动脉僵硬，2型糖尿病和认知表现之间的相互作用。方法：我们研究了(n=197)和(n=528)非2型糖尿病患者，他们完成了神经心理学测试，并接受了压平眼压计和血管超声来评估主动脉(即颈动脉到股的脉搏波速度)和颈动脉硬度(即扩张性、顺应性和杨氏弹性模数)。结果：总体而言，我们的结果表明，颈动脉而不是主动脉僵硬与认知能力较差有关，主要是在处理速度(扩张性标准化回归系数-0.083，p=0.040；顺应性-0.077，p=0.032)以及执行功能和注意力(扩张性-0.133，p=0.001；顺应性-0.090，p=0.015；杨氏弹性系数-0.081，p=0.027)领域。这些关联并不因糖尿病状况而异。2型糖尿病患者与非糖尿病患者认知能力的差异(自由回忆记忆-0.23，加工速度-0.19，执行功能和注意力-0.23)领域得分与非糖尿病患者的平均差异均有统计学意义。
Background and aims: There is increasing evidence linking arterial (mainly aortic) stiffness and type 2 diabetes, a risk factor for arterial stiffness, to cognitive impairment and dementia. However, data on carotid stiffness, which may be especially relevant for cognitive performance, are scarce, and few studies have addressed the interplay between arterial stiffness, type 2 diabetes, and cognitive performance.Methods: We studied individuals with (n = 197) and without (n = 528) type 2 diabetes, who completed a neuropsychological test battery and underwent applanation tonometry and vascular ultrasound to evaluate aortic (i.e. carotid-to-femoral pulse wave velocity) and carotid stiffness (i.e. distensibility, compliance and Young's elastic modulus). Linear regression analyses were performed and adjusted for demographics, vascular risk factors, and depression.Results: Overall, our results showed that carotid, but not aortic, stiffness was associated with worse cognitive performance, primarily in the domains of processing speed (standardized regression coefficient for distensibility -0.083, p = 0.040; compliance -0.077, p = 0.032) and executive function and attention (distensibility -0.133, p = 0.001; compliance -0.090, p = 0.015; Young's elastic modulus -0.081, p = 0.027). These associations did not differ by diabetes status. The differences in cognitive performance between individuals with and without type 2 diabetes (mean difference in domain scores relative to those without diabetes for free recall memory -0.23, processing speed -0.19, executive function and attention -0.23; all p