Evaluation of Medication Adherence and Quality of Life in Patients With Hepatitis C Virus Receiving Combination Therapy
Evaluation of Medication Adherence and Quality of Life in Patients With Hepatitis C Virus Receiving Combination Therapy
复制标题
DOI：
10.1097/sga.0b013e3181f443cb
复制
发表时间：
2010-09-01
影响因子：
0.8
通讯作者：
Kibbe, Pamella
中科院分区：
文献类型：
--
作者：
Rodis, Jennifer L.;Kibbe, Pamella
本研究的目的是确定药物治疗依从性的丙型肝炎病毒（HCV）感染的患者转介到跨学科的HCV教育和监测服务，评价生活质量（QOL）和药物治疗依从性的变化在前3个月的HCV治疗，并确定依从性和QOL之间的关系。然后，他们接受了HCV药物的结构化培训，并在整个治疗过程中每月接受药剂师的监测电话。治疗3个月后，进行随访调查，以评估依从性，满意度和生活质量。还通过患者在电话随访期间的自我报告评估了药物依从性。患者对药剂师和执业护士在HCV治疗期间单独和合作提供的护理表示满意。患者报告在治疗的前3个月内服用了99.8%的干扰素和利巴韦林总剂量。那些表示他们有时会在感觉更糟时停止服用药物的患者有更高的中位综合身体功能评分（p = 0.04），那些没有合并症的患者发现给药时间比那些至少有一种合并症的患者更不方便（p = 0.046）。在药剂师运行的HCV教育服务的患者有很高的自我报告的依从率，并与跨学科的护理模式感到满意。生活质量可能与依从性有关;功能更高，更健康的患者可能更有可能因副作用或不便而停止服用HCV药物。
The purpose of this study was to identify medication adherence for patients infected with hepatitis C virus (HCV) referred to an interdisciplinary HCV education and monitoring service, evaluate changes in quality of life (QOL) and medication adherence during the first 3 months of HCV therapy, and determine relationships between adherence and QOL.Patients completed an initial survey before initiating the therapy evaluating medication adherence and QOL. They then received a structured training on HCV medications and monthly monitoring phone call from a pharmacist throughout the therapy. After 3 months of treatment, a follow-up survey was conducted to evaluate adherence, satisfaction, and QOL. Medication adherence was also assessed via patient self-report during follow-up phone calls. Patients expressed satisfaction with the care provided by the pharmacist and nurse practitioner individually and working collaboratively during their HCV therapy.Patients reported taking 99.8% of total interferon and ribavirin doses during the first 3 months of the therapy. Patients who indicated that they sometimes stopped taking medication when they felt worse had higher median aggregate physical functioning scores (p = .04) and those with no comorbidities found dosage times more inconvenient than those with at least one comorbidity (p = .046). Patients in a pharmacist-run HCV education service have high self-reported adherence rates and are satisfied with the interdisciplinary model of care. Quality of life may be associated with adherence; higher functioning, healthier patients may be more likely to stop taking HCV medications owing to side effects or inconvenience.