EFFECTS OF THERAPY ON PLASMA-HIGH-DENSITY-LIPOPROTEIN-CHOLESTEROL CONCENTRATION IN DIABETES MELLITUS
EFFECTS OF THERAPY ON PLASMA-HIGH-DENSITY-LIPOPROTEIN-CHOLESTEROL CONCENTRATION IN DIABETES MELLITUS
复制标题
治疗对糖尿病血浆高密度脂蛋白胆固醇浓度的影响
DOI：
10.1016/s0140-6736(78)91380-6
复制
发表时间：
1978
期刊：
影响因子：
--
通讯作者：
R. A. Yeates
中科院分区：
文献类型：
--
作者：
G. Calvert;T. Mannik;J. J. Graham;P. Wise;R. A. Yeates
In 122 diabetic patients there was a significant inverse correlation between plasma-high-density-lipoprotein (H.D.L.)-cholesterol concentrations and glycosylated hæmoglobin concentrations. In an insulin-treated subgroup improvement in diabetic control, confirmed by a decrease in glycosylated hæmoglobin concentrations, was accompanied by a significant rise in plasma-H.D.L.-cholesterol concentration. This result suggests that improved diabetic control may diminish the risk of premature ischæmic heart-disease. When three groups of patients on different treatments were matched for age, sex, weight, and diabetic control, diabetic patients receiving sulphonylureas had significantly lower plasma-H.D.L.-cholesterol concentrations than those receiving insulin or on diet alone, or non-diabetic controls. This association suggests that sulphonylurea administration may constitute a positive risk factor for ischæmic heart-disease in diabetic patients.
