The license to pair: Identification of meiotic pairing sites in Drosophila
The license to pair: Identification of meiotic pairing sites in Drosophila
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DOI：
10.1007/bf02509494
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发表时间：
1996-09-01
期刊：
影响因子：
1.6
通讯作者：
McKee, BD
中科院分区：
文献类型：
--
作者：
McKee, BD
在黑腹果蝇雄性和雌性减数分裂中都发现了偶联二价体的配对和分离位点。雄性减数分裂中主要的性染色体配对位点对应于rDNA序列的基因间间隔重复序列，位于X和y的异染色质中。雌性的性染色体配对位点也是异染色质，但涉及不同的重复序列。在男性中，弱配对位点广泛分布在常染色体2号的常染色质上，而不是异染色质上。在2号染色体上发现了雄性减数分裂配对的一个强位点；它与his位点重叠，后者包含组蛋白的重复结构基因。在雌性中，另一个常染色体4号染色体的配对位点被限制在异染色质上。因此，对于性染色体和常染色体来说，非交叉配对的位点在女性中是异色的，而在男性中是正色的（rDNA除外）。讨论了序列重复和转录在染色体配对中的可能作用。
Sites for pairing and segregation of achiasmatic bivalents have been characterized in both male and female meiosis in Drosophila melanogaster. The major sex chromosome pairing site in male meiosis corresponds to the intergenic spacer repeats of the rDNA arrays, which are located in the heterochromatin of the X and Y. The sex chromosome pairing sites in females are also heterochromatic, but involve different repeated sequences. In males, weak pairing sites are widely distributed along euchromatin but not heterochromatin of chromosome 2, an autosome. One strong site for male meiotic pairing has been identified on chromosome 2; it overlaps with the his locus, which contains the repetitive structural genes for the histones. In females the sites for pairing of chromosome 4, another autosome, are restricted to the heterochromatin. Thus for both sex chromosomes and autosomes, sites for achiasmatic pairing are heterochromatic in females but euchromatic (except for the rDNA) in males. The possible roles of sequence repetition and of transcription in chromosome pairing are discussed.