Marked Depletion of Plasma 1,5-Anhydroglucitol, a Major Polyol, in Streptozocin-induced Diabetes in Rats and the Effect of Insulin Treatment
Marked Depletion of Plasma 1,5-Anhydroglucitol, a Major Polyol, in Streptozocin-induced Diabetes in Rats and the Effect of Insulin Treatment
复制标题
链佐星诱导的大鼠糖尿病中血浆 1,5-脱水葡萄糖醇（一种主要多元醇）的显着消耗以及胰岛素治疗的效果
DOI：
10.2337/diab.35.2.204
复制
发表时间：
1986
期刊：
影响因子：
7.7
通讯作者：
Y. Akanuma
中科院分区：
文献类型：
--
作者：
T. Yamanouchi;H. Akanuma;F. Takaku;Y. Akanuma
Plasma levels of 1,5-anhydroglucitol (1,5AG), a major polyol resembling glucose in structure, fell rapidly and dramatically in streptozocin (STZ)-treated rats. 1,5AG fell immediately after STZ injection, reaching a plasma level 6 h after administration of the drug that was one-third that in the plasma of control rats. Reduction of 1,5AG was independent of the profile of blood glucose induced by STZ. After intravenous injection of [14C]-1,5AG, its plasma half-life was determined to be between 120 and 180 min. After a phase of acute decrease, the reduction of 1,5AG became gradual, stopping within 6 days after treatment. However, in some cases, the drop in 1,5AG was partially reversible by insulin treatment. The extent to which 1,5AG fell did not strictly correspond to the dose of STZ. The particular organ(s) consuming or accumulating 1,5AG was not identified. However, aside from the large amount of 1,5AG in plasma and the small amount of 1,5AG in the urine, the liver appears to be a significant organ for metabolism Of 1,5AG.
