17-β estradiol administration attenuates deficits in sustained and divided attention in young ovariectomized rats and aged acyclic female rats
17-β estradiol administration attenuates deficits in sustained and divided attention in young ovariectomized rats and aged acyclic female rats
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DOI：
10.1037/0735-7044.120.6.1225
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发表时间：
2006-12-01
影响因子：
1.9
通讯作者：
Good, M. A.
中科院分区：
文献类型：
--
作者：
Barnes, P.;Staal, V.;Good, M. A.
最近的证据表明，雌激素可能与基底前脑胆碱能系统相互作用，影响学习。作者研究了卵巢切除术后雌激素的丢失（实验1）或衰老过程中雌激素周期的中断（实验2）是否会损害5-选择系列反应时间任务（5-CSRT）的表现-这是一种对大鼠胆碱能挑战敏感的持续和分散注意力任务。在实验1中，年轻大鼠的训练后卵巢切除术并没有破坏基线性能，但不损害性能时，注意力受到挑战的变化，在审讯间隔（ITI）或在间歇性介绍一种新的分散注意力的听觉刺激。17-β雌二醇的管理挽救了这些损害。通过使用的受试者内设计，实验2显示，17-β雌二醇并没有影响的基线性能的21个月大的雌性大鼠训练的5-CSRT任务，从年轻的时候，但提高性能时，注意力受到挑战，通过改变ITI或提出一个分散注意力的听觉线索。结果表明，17-β雌二醇的管理可以提高年轻的卵巢切除大鼠和性腺完整的老年雌性大鼠的注意力的特定组成部分。
Recent evidence suggests that estrogen may interact with the basal forebrain cholinergic system to influence learning. The authors examined whether the loss of estrogen following ovariectomy (Experiment 1) or the disruption to the estrogen cycle during aging (Experiment 2) impaired performance of the 5-choice serial reaction time task (5-CSRT)-a sustained and divided attention task sensitive to cholinergic challenges in rats. In Experiment 1, posttraining ovariectomy in young rats did not disrupt baseline performance but did impair performance when attention was challenged by variation in the intertrial interval (ITI) or in the intermittent presentation of a novel distracting auditory stimulus. Administration of 17-beta estradiol rescued these impairments. Through the use of a within-subjects design, Experiment 2 revealed that 17-beta estradiol did not influence the baseline performance of 21-month-old female rats trained on the 5-CSRT task from a young age but did improve performance when attention was challenged by varying the ITI or by presenting a distracting auditory cue. The results indicate that 17-beta estradiol administration can improve specific components of attention in young ovariectomized rats and gonadally intact aged female rats.