Decorin, a growth hormone-regulated protein in humans
Decorin, a growth hormone-regulated protein in humans
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DOI：
10.1530/eje-17-0844
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发表时间：
2018-02-01
影响因子：
5.8
通讯作者：
Birzniece, Vita
中科院分区：
文献类型：
--
作者：
Bahl, Neha;Stone, Glenn;Birzniece, Vita
背景：生长激素（GH）刺激结缔组织和肌肉生长，这种作用被睾酮增强。Decorin是一种肌因子和结缔组织蛋白，可刺激结缔组织增生和肌肉肥大。生长激素和睾酮是否调节人类的decorin尚不清楚。目的：探讨生长激素和睾酮是否会刺激decorin。设计：随机、安慰剂对照、双盲研究。参与者和干预：96名娱乐性训练的运动员（63名男性，33名女性）接受8周的治疗，然后是6周的洗脱期。男性接受安慰剂、生长激素（2毫克/天）、睾酮（250毫克/周）或联合治疗。妇女接受安慰剂或生长激素（2毫克/天）。主要观察指标：血清decorin浓度。结果：GH治疗显著提高血清decorin平均浓度12.7 +/- 4.2%；P < 0.01。生长激素对decorin的反应存在性别差异，男性高于女性（Delta为16.5 +/- 5.3%,P < 0.05， Delta为9.4 +/- 6.5%,P = 0.16）。睾酮对血清decorin无显著影响。生长激素和睾酮联合治疗可使平均decorin浓度升高19.5±3.7% (P < 0.05)，与单独使用生长激素相比无显著差异。结论：生长激素显著增加循环decorin，其作用在男性中大于女性。Decorin不受睾酮的影响。我们得出结论，生长激素以性别二态的方式正向调节人类的decorin。
Context: Growth hormone (GH) stimulates connective tissue and muscle growth, an effect that is potentiated by testosterone. Decorin, a myokine and a connective tissue protein, stimulates connective tissue accretion and muscle hypertrophy. Whether GH and testosterone regulate decorin in humans is not known.Objective: To determine whether decorin is stimulated by GH and testosterone.Design: Randomized, placebo-controlled, double-blind study.Participants and Intervention: 96 recreationally trained athletes (63 men, 33 women) received 8 weeks of treatment followed by a 6-week washout period. Men received placebo, GH (2 mg/day), testosterone (250 mg/week) or combination. Women received either placebo or GH (2 mg/day).Main outcome measure: Serum decorin concentration.Results: GH treatment significantly increased mean serum decorin concentration by 12.7 +/- 4.2%; P < 0.01. There was a gender difference in the decorin response to GH, with greater increase in men than in women (Delta 16.5 +/- 5.3%; P < 0.05 compared to Delta 9.4 +/- 6.5%; P = 0.16). Testosterone did not significantly change serum decorin. Combined GH and testosterone treatment increased mean decorin concentration by 19.5 +/- 3.7% (P < 0.05), a change not significantly different from GH alone.Conclusion: GH significantly increases circulating decorin, an effect greater in men than in women. Decorin is not affected by testosterone. We conclude that GH positively regulates decorin in humans in a gender-dimorphic manner.