Immunological relationship between anionic antimicrobial proteins from caries-free individuals and known salivary antimicrobial factors
Immunological relationship between anionic antimicrobial proteins from caries-free individuals and known salivary antimicrobial factors
复制标题
无龋齿个体阴离子抗菌蛋白与已知唾液抗菌因子之间的免疫学关系
作者：
S. D. Obenauf;R. H. Fisher;R. Cowman;R. Fitzgerald
我们检查了在某些无龋齿个体的混合唾液中鉴定出的阴离子抑制蛋白是否是公认的唾液抗菌因子的片段或降解产物。在此报告的实验中，阴离子抑制蛋白不会与任何已检测的唾液抗菌因子的抗血清产生沉淀反应。此外，天然的、热处理的或尿素变性的已知唾液抗微生物因子不与阴离子抑制蛋白的抗血清反应。然而，发现阴离子抑制蛋白的抗血清与来自混合唾液或来自许多不同供体的单独下颌下和腮腺分泌物的蛋白浓缩物以及含有同源阴离子抑制蛋白的纯化蛋白级分发生反应。这些发现表明阴离子抑制蛋白代表完整且独特的唾液蛋白，而不是口腔环境中唾液抗菌蛋白因子的降解片段。
We examined whether the anionic inhibitory proteins identified in mixed saliva from certain caries-free individuals are fragments or degradation products of recognized salivary antimicrobial factors. In the experiments reported here, the anionic inhibitory proteins did not produce precipitin reactions with antisera to any of the established salivary antimicrobial factors examined. Additionally, native, heat-treated, or urea-denatured known salivary antimicrobial factors did not react with the antiserum to the anionic inhibitory proteins. However, the antiserum to the anionic inhibitory proteins was found to be reactive with a protein concentrate from mixed saliva or from separate submandibular and parotid secretions from a number of different donors, as well as with a purified protein fraction containing the homologous anionic inhibitory proteins. These findings suggest that the anionic inhibitory proteins represent intact and unique salivary proteins and not the degradation fragments of salivary antimicrobial protein factors within the oral environment.
人中性粒细胞髓过氧化物酶的分离和特性。
影响因子：
2.9
作者：
Matheson,NR;Wong,PS;Travis,J
通讯作者：
Travis,J