EXPRESSION OF THE V-SRC OR V-FPS ONCOGENE INCREASES FRUCTOSE 2,6-BISPHOSPHATE IN CHICK-EMBRYO FIBROBLASTS - NOVEL MECHANISM FOR THE STIMULATION OF GLYCOLYSIS BY RETROVIRUSES
EXPRESSION OF THE V-SRC OR V-FPS ONCOGENE INCREASES FRUCTOSE 2,6-BISPHOSPHATE IN CHICK-EMBRYO FIBROBLASTS - NOVEL MECHANISM FOR THE STIMULATION OF GLYCOLYSIS BY RETROVIRUSES
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DOI：
10.1042/bj2360595
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发表时间：
1986-06-01
影响因子：
4.1
通讯作者：
HUE, L
中科院分区：
文献类型：
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作者：
BOSCA, L;MOJENA, M;HUE, L
果糖2，6-二磷酸的浓度和6-磷酸果糖-2-激酶的活性增加后，感染鸡胚成纤维细胞与劳斯肉瘤病毒，或与该病毒的温度敏感突变体在允许的，但不是在非允许的，温度。这在通过携带v-src或v-fps而不是v-mil和/或v-myc癌基因的逆转录病毒转化后观察到。劳斯肉瘤病毒与佛波醇肉豆蔻酸酯乙酸酯对果糖2，6-二磷酸的作用的比较表明，两者都是由对6-磷酸果糖-2-激酶活化限速的步骤的刺激引起的，该步骤也由蛋白激酶C控制。
The concentration of fructose 2,6-bisphosphate and the activity of 6-phosphofructo-2-kinase are increased after infection of chick-embryo fibroblasts with the Rous sarcoma virus, or with a temperature-sensitive mutant of this virus at the permissive, but not at the non-permissive, temperature. This is observed after transformation by retroviruses carrying either the v-src or v-fps, but not the v-mil and/or v-myc, oncogenes. Comparsion of the effects of the Rous sarcoma virus with those of phorbol myristate acetate on fructose 2,6-bisphosphate suggests that both result from the stimulation of a step which is rate-limiting for 6-phosphofructo-2-kinase activation and which is also controlled by protein kinase C.