Drug Insight: using statins to treat neuroinflammatory disease.
Drug Insight: using statins to treat neuroinflammatory disease.
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药物洞察：使用他汀类药物治疗神经炎症性疾病。
DOI：
10.1038/ncpneuro0047
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发表时间：
2005
影响因子：
--
通讯作者：
Zamvil,ScottS
中科院分区：
文献类型：
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作者：
Weber,MartinS;Prod'homme,Thomas;Steinman,Lawrence;Zamvil,ScottS
他汀类药物是3-羟基-3-甲基戊二酰辅酶A还原酶抑制剂的一个家族，主要用于减少动脉粥样硬化和心血管发病率。令人惊讶的是，它们还显示出具有免疫调节特性，这可能有利于治疗自身免疫性疾病。他汀类药物可以预防甚至逆转实验性自身免疫性脑脊髓炎（多发性硬化症的小鼠模型）中的持续性瘫痪，基于这些发现，他汀类药物目前正在多发性硬化症患者的临床试验中进行测试。
Statins, a family of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, are used primarily to reduce atherogenesis and cardiovascular morbidity. Surprisingly, they have also been shown to have immunomodulatory properties that might be of benefit for the treatment of autoimmune disorders. Statins can prevent and even reverse ongoing paralysis in experimental autoimmune encephalomyelitis—the mouse model for multiple sclerosis—and on the basis of these findings, statins are now being tested in patients with multiple sclerosis in clinical trials.