Juxtamembrane contribution to transmembrane signaling.
Juxtamembrane contribution to transmembrane signaling.
复制标题
作者：
Deng W;Li R
跨膜受体介导的跨细胞膜信号转导在多种生物过程中发挥着重要作用。最近的研究表明，在许多单跨跨膜受体中，连接跨膜螺旋和细胞质结构域其余部分的细胞内膜旁序列(JM)通过几种新的机制直接参与信号传递过程。本文简要介绍了不同类型的跨膜受体在信号转导方面所共有的几种JM动力学模式。
Signaling across the cell membrane mediated by transmembrane receptors plays an important role in diverse biological processes. Recent studies have indicated that, in a number of single-span transmembrane receptors, the intracellular juxtamembrane (JM) sequence linking the transmembrane helix with the rest of the cytoplasmic domain participates directly in the signaling process via several novel mechanisms. This review briefly highlights several modes of JM dynamics in the context of signal transduction that are shared by different types of transmembrane receptors.