Gene of LukF-PV-like component of Panton-Valentine leukocidin in Staphylococcus aureus P83 is linked with lukM
Gene of LukF-PV-like component of Panton-Valentine leukocidin in Staphylococcus aureus P83 is linked with lukM
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DOI：
10.1271/bbb.61.541
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发表时间：
1997-03-01
影响因子：
1.6
通讯作者：
Kamio, Y
中科院分区：
文献类型：
--
作者：
Kaneko, J;Muramoto, K;Kamio, Y
金黄色葡萄球菌P83（ATCC 31890）产生五种组分，即协同毒素、杀白细胞素和γ-溶血素的I至V [Sudo等人，生物科学，生物技术，生物化学，56，1786-1789（1995）]。我们在这里报告的鉴定组分II，这是指定的LukF-PV（P83）和它的基因（lukF-PV（P83））。发现lukF-PV（P83）基因位于lukM基因终止密码子下游一个碱基处。LukF-PV（P83）的氨基酸序列与LukF-PV的同源性为78.4%。lukM和lukF-PV（P83）基因与Panton-Valentine杀白细胞素基因类似，为一个操纵子。
Staphylococcus aureus P83 (ATCC 31890) produces five components, I to V for synergistic toxins, leukocidin and gamma-hemolysin [Sudo et al., Biosci, Biotech, Biochem., 56, 1786-1789 (1995)]. We report here the identification of component II, which is designated LukF-PV(P83) and its gene (lukF-PV(P83)). The lukF-PV(P83) gene was found to be one base downstream of the stop codon of the lukM gene. The deduced amino acid sequence of LukF-PV(P83) showed 78.4% identity with that of LukF-PV, The lukM and lukF-PV(P83) genes were encoded as one operon like that of Panton-Valentine leukocidin.