A Micro Peristaltic Pump Using an Optically Controllable Bioactuator
A Micro Peristaltic Pump Using an Optically Controllable Bioactuator
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DOI：
10.1016/j.eng.2018.11.033
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发表时间：
2019-06-01
期刊：
影响因子：
12.8
通讯作者：
Morishima, Keisuke
中科院分区：
文献类型：
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作者：
Yamatsuta, Eitaro;Beh, Sze Ping;Morishima, Keisuke
蠕动在自然界中广泛存在，因为这种泵送作用在消化系统中很重要，可以将营养输送到身体的每个角落。在本文中，我们提出了一种肌肉驱动的管状微泵，提供蠕动输送。我们利用果蝇幼虫表达通道视紫红质-2（ChR 2）的细胞膜上的骨骼肌，以获得光响应的肌肉组织。幼虫在蓝光刺激下被迫收缩。当改变传播光刺激的速度时，我们观察到收缩肌肉组织表面的位移。我们通过将幼虫解剖成管状结构来获得蠕动泵。管状结构的平均内径约为400 μ m，平均外径约为750 μ m。这种管状结构的收缩可以用相同的蓝光刺激来控制。为了使内部流动可见，我们将微珠放入蠕动泵中，从而确定该泵可以以120 μ m.s（-1）的速度输送微珠。(C)2019年，《The Comorers》。由爱思唯尔有限公司代表中国工程院和高等教育出版社有限公司出版。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Peristalsis is widely seen in nature, as this pumping action is important in digestive systems for conveying sustenance to every corner of the body. In this paper, we propose a muscle-powered tubular micro pump that provides peristaltic transport. We utilized Drosophila melanogaster larvae that express channelrhodopsin-2 (ChR2) on the cell membrane of skeletal muscles to obtain light-responsive muscle tissues. The larvae were forced to contract with blue light stimulation. While changing the speed of the propagating light stimulation, we observed displacement on the surface of the contractile muscle tissues. We obtained peristaltic pumps from the larvae by dissecting them into tubular structures. The average inner diameter of the tubular structures was about 400 mu m and the average outer diameter was about 750 mu m. Contractions of this tubular structure could be controlled with the same blue light stimulation. To make the inner flow visible, we placed microbeads into the peristaltic pump, and thus determined that the pump could transport microbeads at a speed of 120 mu m.s(-1). (C) 2019 THE AUTHORS. Published by Elsevier LTD on behalf of Chinese Academy of Engineering and Higher Education Press Limited Company. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).