Hormonal Interactions in the Effects of Halogenated Aromatic Hydrocarbons On the Developing Brain
Hormonal Interactions in the Effects of Halogenated Aromatic Hydrocarbons On the Developing Brain
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卤代芳烃对大脑发育影响的激素相互作用
DOI：
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发表时间：
1998
影响因子：
1.9
通讯作者：
R. Peterson
中科院分区：
文献类型：
--
作者：
N. MacLusky;T. Brown;S. Schantz;Byung Woun Seo;R. Peterson
卤代芳烃（HAH）对发育中的大脑产生广泛的影响。这些影响导致成年后神经内分泌功能和行为模式的改变，以及认知功能的变化。其基本机制尚未明确界定。本文简要回顾了HAH对脑发育的影响，并提出了不同的脑敏感系统之间的相互作用可能有助于胎儿或出生后早期HAH暴露后观察到的广谱反应的假设。已知性类固醇、皮质类固醇和甲状腺激素的作用之间的生理相互作用会影响中枢神经系统（CNS）的发育。由于这些激素的生物合成和/或行动是敏感的发展HAH曝光，它建议，不同的内分泌途径的HAH的会聚效应可能是这些化学品对中枢神经系统分化的一些破坏性影响的基础。数据表明，低剂量二恶英暴露对大鼠大脑性别分化的破坏性影响可能不是通过阻断雌激素反应介导的，而是可能涉及其他内分泌系统的微妙的发育变化，也许还影响肾上腺皮质功能的反馈控制。潜在的相互作用的内分泌效应说明需要更全面地了解的生物活性的范围内的多环芳烃在大脑中，这样的潜在风险的低剂量发育暴露于这些环境毒物可以预测更大的把握。
Halogenated arylhydrocarbons (HAHs) exert a wide range of effects on the developing brain. These effects result in altered patterns of neuroendocrine function and behavior in adulthood, as well as changes in cognitive function. The underlying mechanisms have not yet been clearly defined. This paper briefly reviews the effects of HAHs on brain development, and proposes the hypothesis that interactions between different hormone-sensitive systems may contribute to the broad spectrum of responses observed after fetal or early postnatal HAH exposure. Physiological interactions between the effects of sex steroids, corticosteroids, and thyroid hormone are known to influence the development of the central nervous system (CNS). Since the biosynthesis and/or action of each of these hormones is sensitive to developmental HAH exposure, it is suggested that convergent effects of HAHs on different endocrine pathways may underlie some of the disruptive effects of these chemicals on CNS differentiation. Data are presented indicating that the disruptive effects of low dose dioxin exposure on sexual differentiation of the rat brain are probably not mediated through blockade of estrogen responses, butmay instead involve subtle developmental changes in other endocrine systems, perhaps also affecting the feedback control of adrenocortical function. The potential for interactive endocrine effects illustrates the need for a fuller understanding of the range of biological activities of HAHs in the brain, so that the potential risks of low dose developmental exposure to these environmental toxicants can be predicted with greater certainty.
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