Tracking Associations Between Ambient Ozone and Asthma-Related Emergency Department Visits Using Case-Crossover Analysis
Tracking Associations Between Ambient Ozone and Asthma-Related Emergency Department Visits Using Case-Crossover Analysis
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DOI：
10.1097/01.phh.0000338371.53242.0e
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发表时间：
2008-11-01
影响因子：
3.3
通讯作者：
Smith, Andy E.
中科院分区：
文献类型：
--
作者：
Paulu, Chris;Smith, Andy E.
传统的环境公共卫生监测包括分别测量危害、暴露和健康结果。环境公共卫生跟踪网络试图通过将危害或接触数据与健康结果数据联系起来，积累更多的信息。一个自然的进展是考虑跟踪“联系”本身，即跟踪环境危害与健康结果之间的关联。缅因州EPHT项目进行了一项病例交叉分析，以测量2000-2003年每日估计的环境臭氧和颗粒物（PM2.5）与哮喘相关急诊（艾德）就诊之间的关联。我们发现，在4天内（滞后0-3），臭氧平均每增加10 ppb，哮喘相关艾德就诊率为7%（95%置信区间，4-11）。前3年为正相关，后3年为负相关。过度风险集中在15至34岁的女性和15岁以下的男性。追踪环境空气质量和急性发病率之间关联的方法并不能推广到大多数其他EPHT主题领域，但有充分的理由进行这项活动。该分析可能有助于评估监管和干预计划的有效性，并告知我们有关趋势，敏感亚群和空气成分变化的潜力。
Traditional environmental public health surveillance consists of separately measuring hazards, exposures, and health outcomes. The Environmental Public Health Tracking (EPHT) Network seeks to accrue additional information by linking hazard or exposure data to health outcomes data. A natural progression is to consider tracking the "link" itself, that is, to track the association between an environmental hazard and a health outcome. The Maine EPHT Program conducted a case-crossover analysis to measure associations between daily estimated ambient ozone and particulate matter (PM2.5) and asthma-related emergency department (ED) visits for 2000-2003. We found an overall association of 7 percent (95% confidence interval, 4-11) excess asthma-related ED visits per 10-ppb increase in ozone averaged over 4 days (lag 0-3). The association was positive in the first 3 years and negative in the last. The excess risk was concentrated among females aged 15 to 34 and males younger than 15. The methodology for tracking associations between ambient air quality and acute morbidity is not generalizable to most other EPHT topic areas, but there are ample reasons to pursue this activity. The analysis can potentially help evaluate the effectiveness of regulatory and intervention programs, as well as inform us about trends, sensitive subpopulations, and changing potency of air constituents.