Tbr1 regulates differentiation of the preplate and layer 6
Tbr1 regulates differentiation of the preplate and layer 6
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DOI：
10.1016/s0896-6273(01)00211-2
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发表时间：
2001-02-01
期刊：
影响因子：
16.2
通讯作者：
Rubenstein, JLR
中科院分区：
文献类型：
--
作者：
Hevner, RF;Shi, LM;Rubenstein, JLR
在皮质生成过程中，前板和第6层的早期神经元对于指导随后的神经元迁移和轴突投射是重要的。Tbr 1是一种假定的转录因子，在海马神经元中高度表达。在Tbr 1缺陷小鼠中，这些早期出生的神经元具有分子和功能缺陷。Cajal-Retzius细胞表达的Reelin水平降低，导致了一种卷轴样皮质迁移障碍。亚板分化受损与丘脑皮质纤维异位投射到基底端脑有关。第6层缺陷导致丘脑皮质、皮质丘脑和胼胝体投射错误。这些结果表明，Tbr 1是一个共同的遗传决定因素的分化早期出生的mammatergic新皮层神经元，并提供洞察这些神经元的功能，作为监管机构的皮层发育。
During corticogenesis, early-born neurons of the pre-plate and layer 6 are important for guiding subsequent neuronal migrations and axonal projections. Tbr1 is a putative transcription factor that is highly expressed in glutamatergic early-born cortical neurons. In Tbr1-deficient mice, these early-born neurons had molecular and functional defects. Cajal-Retzius cells expressed decreased levels of Reelin, resulting in a reeler-like cortical migration disorder. Impaired subplate differentiation was associated with ectopic projection of thalamocortical fibers into the basal telencephalon. Layer 6 defects contributed to errors in the thalamocortical, corticothalamic, and callosal projections. These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development.