Novel mutations in FATP4 gene in two families with ichthyosis prematurity syndrome
Novel mutations in FATP4 gene in two families with ichthyosis prematurity syndrome
复制标题
两个鱼鳞病早产综合征家系FATP4基因新突变
DOI：
10.1111/jdv.13584
复制
发表时间：
2017
影响因子：
9.2
通讯作者：
Rogelio González
中科院分区：
文献类型：
--
作者：
Elena Bueno;Javier Cañueto;Vicente García;M. A. Vicente;D. Bodet;M. E. Hernández;Rogelio González
能增加银屑病皮肤中survivin和caspase 3基因及蛋白的表达，提示依那西普的作用机制与银屑病角质形成细胞凋亡的增加及其以survivin为代表的生理制动系统有关。特别地，这些发现与Gambichler等人观察到UVB联合依那西普治疗银屑病皮肤的survivin表达比UVB单药治疗显著增加一致，证明依那西普治疗本身可以增强银屑病皮肤的survivin。总之，我们的结果强调了依那西普治疗能够干扰复制、增殖、存活和凋亡。在后两种机制中观察到更明显的活性，其新颖性在于调节伴随的细胞凋亡和存活的能力，可能避免了这些复杂途径中危险的不平衡。这项研究部分由意大利辉瑞公司赞助。S. Lembo， N. Balato， G. Caiazzo， M. Megna， F. Ayala， A. Balato*那不勒斯大学皮肤科，Federico II，那不勒斯，意大利*通讯：A. Balato电子邮件:annabalato@yahoo.it
was able to increase both survivin and caspase 3 gene and protein expression in psoriatic skin, suggesting that etanercept mechanism of action is linked to the increase of psoriatic keratinocytes apoptosis and of its physiological brake system, represented by survivin. Particularly, these findings are in line with Gambichler et al. who observed significant increase in survivin expression in UVB plus etanercept-treated psoriatic skin as compared with UVB monotherapy, proving that etanercept treatment could itself enhance survivin in psoriatic skin. In conclusion, our results highlighted that etanercept treatment was able to interfere with replication, proliferation, survival, and apoptosis. A more pronounced activity was observed in the latter two mechanisms, with the novelty consisting in the ability to modulate concomitant apoptosis and survival, possibly avoiding dangerous disequilibrium in these complex pathways. This study was partially sponsored by Pfizer, Italy. S. Lembo, N. Balato, G. Caiazzo, M. Megna, F. Ayala, A. Balato* Department of Dermatology, University of Naples Federico II, Naples, Italy *Correspondence: A. Balato. E-mail: annabalato@yahoo.it