Local potential gradients as a unifying measure for thresholds of stimulation, standstill, tachyarrhythmia and fibrillation appearing after strong capacitor discharges.
Local potential gradients as a unifying measure for thresholds of stimulation, standstill, tachyarrhythmia and fibrillation appearing after strong capacitor discharges.
复制标题
局部电位梯度作为强电容器放电后出现的刺激、静止、快速心律失常和颤动阈值的统一测量。
作者：
E. Lepeschkin;J. Jones;S. Rush;R. E. Jones
作者在培养的鸡胚胎心肌细胞中观察到电容器放电振幅增加后的心律失常模式，并将其与文献中报道的实验动物和人类由类似放电引起的心律失常模式进行了比较。各类型心律失常的绝对电压和绝对电流变化较大，但以心肌组织峰值电流密度为基础重新计算刺激水平时，离散性明显减小，以细胞水平峰值电位梯度为共同比较基础时，离散性进一步减小。心律失常模式和发生时的电压梯度的相似性表明，这些心律失常的机制在培养细胞和完整的动物和人类中可能是相似的。
The pattern of arrhythmias following capacitor discharges of increasing amplitude, which have been observed by the authors in cultured myocardial cells from chick embryos, was compared to the arrhythmia patterns caused by similar discharges in experimental animals and humans, as reported in the literature. While the absolute voltages and currents causing each type of arrhythmia showed great variation, the scatter decreased considerably when the stimulus level was recalculated on the basis of peak current density in myocardial tissue, and was reduced further when the peak potential gradient at the cell level was used as the common basis of comparison. The similarity in the arrhythmia patterns and in the voltage gradients at which they occur indicates that the mechanism of these arrhythmias may be similar in cultured cells and intact animals and humans.