Spectral domain optical coherence tomography (SD-OCT) assessment of the healthy female canine retina and optic nerve
Spectral domain optical coherence tomography (SD-OCT) assessment of the healthy female canine retina and optic nerve
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DOI：
10.1111/j.1463-5224.2011.00887.x
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发表时间：
2011-11-01
影响因子：
1.6
通讯作者：
Grozdanic, Sinisa D.
中科院分区：
文献类型：
--
作者：
Hernandez-Merino, Elena;Kecova, Helga;Grozdanic, Sinisa D.
目的应用光谱域光学相干断层扫描技术测量犬视网膜整体厚度(WRT)、神经纤维层厚度(NFL)、感光细胞层厚度(PR)和外核层厚度(ONL)，并对12只健康成年雌性比格犬进行水平容积扫描，测量视网膜NFL、PR、ONL和WRT。采用乳头周围环状扫描评价神经纤维层厚度。统计分析比较上下视网膜各层厚度(配对t检验)。结果视网膜上象限、下象限、颞象限和鼻象限NFL厚度分别为198.7±9.6µm和164.4±6.4µm，P<；0.0001；95.5±/-6.5µm和78.8±7.4µm，P<；0.0001；和26.4+/-1.6亩与25.0+/-1.9亩，P=0.0236)。上、下视网膜ONL厚度分别为50.1umvs.44.3um，差异无统计学意义(P=0.0578)。上象限厚度最大(91.2 6±-7.0 mm)，下象限最薄(76.42±-9.2um m)(P<；0.001)。结论活体研究结果显示，视网膜上(绒)层和下(非)层厚度存在显著差异。
Objective To provide normative data for canine whole retinal thickness (WRT), nerve fiber layer thickness (NFL), photoreceptor layer thickness (PR), and outer nuclear layer thickness (ONL) using spectral domain optical coherence tomography.Animals studied Twelve healthy adult intact female beagles.Procedure Horizontal volume scans through the area dorso-temporal from the optic nerve (superior retina), and the area ventro-temporal from the optic nerve (inferior retina) were used to evaluate the thickness of retinal NFL, PR, ONL, and WRT. Peripapillary circular scans were used to evaluate NFL thickness. Statistical analyses were performed to compare the thickness of the individual layers between the superior and inferior retina (paired t-test). One-way analysis of variance (ANOVA) was used to compare the thickness of peripapillary NFL between the superior, inferior, temporal and nasal quadrants of the circle scan.Results The WRT, PR, and NFL thickness were greater in the superior than in the inferior retina (198.7 +/- 9.6 mu m vs. 164.4 +/- 6.4 mu m, P < 0.0001; 95.5 +/- 6.5 mu m vs. 78.8 +/- 7.4 mu m, P < 0.0001; and 26.4 +/- 1.6 mu m vs. 25.0 +/- 1.9 mu m, P = 0.0236, respectively). No statistical difference was found between the ONL thickness of the superior and inferior retina (50.1 +/- 6.4 mu m vs. 44.3 +/- 3.6, P = 0.0578). Peripapillary NFL thickness showed a similar tendency as the linear scans, with the superior quadrant having the greatest thickness (91.26 +/- 7.0 mu m) and the inferior quadrant being the thinnest (76.42 +/- 9.2 mu m) (P < 0.001).Conclusions Results of our in vivo studies showed significant differences between thickness values for the superior (tapetal) and inferior (nontapetal) retinal regions.