Being Present: A single-arm feasibility study of audio-based mindfulness meditation for colorectal cancer patients and caregivers.
Being Present: A single-arm feasibility study of audio-based mindfulness meditation for colorectal cancer patients and caregivers.
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DOI：
10.1371/journal.pone.0199423
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Dhruva A
中科院分区：
文献类型：
--
作者：
Atreya CE;Kubo A;Borno HT;Rosenthal B;Campanella M;Rettger JP;Joseph G;Allen IE;Venook AP;Altschuler A;Dhruva A
转移性癌症诊断与患者和护理人员的高水平痛苦相关。正念干预可以减少癌症患者的痛苦并提高生活质量。然而，标准的正念训练依赖于面对面的指导，这对于接受化疗的患者或他们的照顾者来说往往是不切实际的。在“在场”单臂试点研究中，我们设计并测试了一项为期8周的基于音频的正念冥想计划，该计划适用于接受化疗的转移性结直肠癌患者，无论是否有参与护理人员。该研究在9个月内招募了74名合格患者中的33名（45%）和20名家庭护理人员（共53名参与者）。41名参与者可评价（77%）; 12例损耗中有10例归因于住院或死亡。中位参与者年龄为51岁（范围21-78岁）; 38%为男性。患者和照顾者的基线痛苦水平相似。干预前访谈中提到的参与的主要原因是增加放松/平静，改善情绪/情绪，减少压力/焦虑。在坚持的措施，59%的回应每周短信问：“你今天练习了吗？”59%的受访者表示练习时间超过50%。与基线相比，干预后调查显示，痛苦（p = 0.01）和焦虑（p = 0.03）显著减少;以及无反应性（p<0.01）和平静感（p<0.01）增加。干预后定性访谈，其中71%的参与者报告受益，与定量结果一致。在访谈中，参与者自发地描述了减少的压力/焦虑和增加的放松/平静。与未配对的患者相比，患者-护理人员配对的获益似乎更明显。79%的参与者报告了在研究完成后继续练习的计划。我们的结论是，在场的音频为基础的正念冥想计划是感兴趣的，可行的，并接受转移性结直肠癌患者和照顾者，初步证据的疗效。这些结果将指导后续研究的计划。试用注册：ClinicalTrials.gov NCT 02423720
A metastatic cancer diagnosis is associated with high levels of distress in patients and caregivers. Mindfulness interventions can reduce distress and improve quality of life in cancer patients. However, standard mindfulness training relies on in-person instruction, which is often not practical for either patients receiving chemotherapy or their caregivers. In the Being Present single arm pilot study, we designed and tested an 8-week audio-based mindfulness meditation program for patients with metastatic colorectal cancer receiving chemotherapy with or without a participating caregiver. The study accrued 33 of 74 (45%) eligible patients consenting together with 20 family caregivers (53 participants total) within nine months. Forty-one participants were evaluable (77%); 10 of 12 cases of attrition were attributable to hospitalization or death. Median participant age was 51 (range 21–78 years); 38% were men. Baseline levels of distress were similar in patients and caregivers. The top reasons for participation cited in pre-intervention interviews were to increase relaxation/calm, improve mood/emotions, and reduce stress/anxiety. In measures of adherence, 59% of responses to weekly texts asking: “Have you practiced today?” were “Yes” and 59% of interviewees reported practicing >50% of the time. Compared to baseline, post-intervention surveys demonstrated significantly reduced distress (p = 0.01) and anxiety (p = 0.03); as well as increased non-reactivity (p<0.01), and feeling at peace (p<0.01). Post-intervention qualitative interviews, where 71% of participants reported benefit, were consistent with quantitative findings. In the interviews, participants spontaneously described reduced stress/anxiety and increased relaxation/calm. Benefits appeared to be accentuated in patient-caregiver pairs as compared to unpaired patients. Seventy-nine percent of participants reported plans for continued practice after study completion. We conclude that the Being Present audio-based mindfulness meditation program is of interest to, feasible, and acceptable for patients with metastatic colorectal cancer and caregivers, with initial evidence of efficacy. These results will guide plans for a follow-up study. Trial registration: ClinicalTrials.gov NCT02423720
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影响因子：
5.4
作者：
Hodges, LJ;Humphris, GM;Macfarlane, G
通讯作者：
Macfarlane, G
DOI：
10.13063/2327-9214.1015
发表时间：
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期刊：
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10.6004/jnccn.2016.0165
发表时间：
2016-12-01
影响因子：
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