A Window on the Lung: Molecular Imaging as a Tool to Dissect Pathophysiologic Mechanisms of Acute Lung Disease.
A Window on the Lung: Molecular Imaging as a Tool to Dissect Pathophysiologic Mechanisms of Acute Lung Disease.
复制标题
肺部之窗：分子成像作为剖析急性肺部疾病病理生理机制的工具。
DOI：
10.1155/2019/1510507
复制
发表时间：
2019
影响因子：
--
通讯作者：
Musch,Guido
中科院分区：
文献类型：
--
作者：
Musch,Guido
近年来，影像学对我们理解急性肺部疾病的病理生理学做出了重要贡献。基于计算机断层扫描（CT）、正电子发射断层扫描（PET）和磁共振（MR）成像，已经开发了几种方法，这些方法允许对诸如肺应变、肺泡大小、炎性细胞的代谢活性、通气和灌注的变量进行局部体内测量。由于这些方法中有几种是非侵入性的，因此可以成功地从动物模型转化为患者。本文的目的是回顾这些成像方式在急性呼吸窘迫综合征（ARDS）、呼吸机诱导的肺损伤（VILI）、哮喘和慢性阻塞性肺疾病（COPD）病理生理学方面的知识进展。
In recent years, imaging has given a fundamental contribution to our understanding of the pathophysiology of acute lung diseases. Several methods have been developed based on computed tomography (CT), positron emission tomography (PET), and magnetic resonance (MR) imaging that allow regional, in vivo measurement of variables such as lung strain, alveolar size, metabolic activity of inflammatory cells, ventilation, and perfusion. Because several of these methods are noninvasive, they can be successfully translated from animal models to patients. The aim of this paper is to review the advances in knowledge that have been accrued with these imaging modalities on the pathophysiology of acute respiratory distress syndrome (ARDS), ventilator‐induced lung injury (VILI), asthma and chronic obstructive pulmonary disease (COPD).